about
In vivo functional requirement of the mouse Ifitm1 gene for germ cell development, interferon mediated immune response and somitogenesisFGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellumPhenotypic annotation of the mouse X chromosomeGene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleasesTarget validation in mice by constitutive and conditional RNAi.Humanized c-Myc mouseDevelopment of an intein-mediated split-Cas9 system for gene therapyEfficient generation of rat induced pluripotent stem cells using a non-viral inducible vector.Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.An RNAi-based approach to down-regulate a gene family in vivo.Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotesModeling disease mutations by gene targeting in one-cell mouse embryosDirect production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.Highly efficient targeted mutagenesis in mice using TALENsLocal knockdown of ERK2 in the adult mouse brain via adeno-associated virus-mediated RNA interference.Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line.Overview on mouse mutagenesis.The functional annotation of mammalian genomes: the challenge of phenotyping.Conditional RNAi in mice.Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA.Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.Fusion of SpCas9 to E. coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells.Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9.Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells.Caspase-mediated apoptosis induction in zebrafish cerebellar Purkinje neurons.Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo.Gene knockdown in the mouse through RNAi.CD19-independent instruction of murine marginal zone B-cell development by constitutive Notch2 signaling.Reversible and tissue-specific activation of MAP kinase signaling by tamoxifen in Braf(V637)ER(T2) mice.Control of gene editing by manipulation of DNA repair mechanisms.Gene editing and clonal isolation of human induced pluripotent stem cells using CRISPR/Cas9.Pink1-deficiency in mice impairs gait, olfaction and serotonergic innervation of the olfactory bulb.Gene editing in mouse zygotes using the CRISPR/Cas9 system.Genome Editing in Mice Using TALE Nucleases.Generation of targeted mouse mutants by embryo microinjection of TALENs.Genetic mouse models for behavioral analysis through transgenic RNAi technology.Gene Editing in One-Cell Embryos by Zinc-Finger and TAL Nucleases.Constitutive and conditional RNAi transgenesis in mice.Generation of shRNA transgenic mice.The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Ralf Kühn
@ast
Ralf Kühn
@en
Ralf Kühn
@es
Ralf Kühn
@nl
Ralf Kühn
@sl
type
label
Ralf Kühn
@ast
Ralf Kühn
@en
Ralf Kühn
@es
Ralf Kühn
@nl
Ralf Kühn
@sl
prefLabel
Ralf Kühn
@ast
Ralf Kühn
@en
Ralf Kühn
@es
Ralf Kühn
@nl
Ralf Kühn
@sl
P1053
U-1278-2017
P106
P21
P31
P496
0000-0003-1694-9803