Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.
about
Oligonucleotide-directed mutagenesis for precision gene editingDesigned nucleases for targeted genome editingTranscription activator-like effectors: a toolkit for synthetic biologyMaking designer mutants in model organismsUnderstanding cardiac sarcomere assembly with zebrafish geneticsThe position of DNA cleavage by TALENs and cell synchronization influences the frequency of gene editing directed by single-stranded oligonucleotidesPrecise gene modification mediated by TALEN and single-stranded oligodeoxynucleotides in human cellsOne-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineeringA robust TALENs system for highly efficient mammalian genome editing.Next-generation mammalian genetics toward organism-level systems biologyEfficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases.Mouse genome engineering using designer nucleases.Application of oocyte cryopreservation technology in TALEN-mediated mouse genome editingTALEN and CRISPR/Cas Genome Editing Systems: Tools of Discovery.Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs.2015 Guidelines for Establishing Genetically Modified Rat Models for Cardiovascular Research.Transgenic mouse model expressing P53(R172H), luciferase, EGFP, and KRAS(G12D) in a single open reading frame for live imaging of tumor.Creation of targeted genomic deletions using TALEN or CRISPR/Cas nuclease pairs in one-cell mouse embryos.Efficient knockin mouse generation by ssDNA oligonucleotides and zinc-finger nuclease assisted homologous recombination in zygotesThe kick-in system: a novel rapid knock-in strategy.Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research.Genetically engineered humanized mouse models for preclinical antibody studies.Inducible and reversible lentiviral and Recombination Mediated Cassette Exchange (RMCE) systems for controlling gene expression.Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR.Controlled delivery of β-globin-targeting TALENs and CRISPR/Cas9 into mammalian cells for genome editing using microinjectionPreclinical Models Provide Scientific Justification and Translational Relevance for Moving Novel Therapeutics into Clinical Trials for Pediatric Cancer.TALEN-mediated homologous recombination in Daphnia magna.ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes.Generation of TALE nickase-mediated gene-targeted cows expressing human serum albumin in mammary glands.Genome engineering: Drosophila melanogaster and beyondEfficient genetic manipulation of the NOD-Rag1-/-IL2RgammaC-null mouse by combining in vitro fertilization and CRISPR/Cas9 technology.Allele-Specific Quantitative PCR for Accurate, Rapid, and Cost-Effective Genotyping.Germline modification of domestic animals.Efficient nonmeiotic allele introgression in livestock using custom endonucleasesHighly efficient targeted mutagenesis in mice using TALENsEfficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease.Highly efficient CRISPR/Cas9-mediated knock-in in zebrafish by homology-independent DNA repair.A modified TALEN-based strategy for rapidly and efficiently generating knockout mice for kidney development studies.TALEN-mediated single-base-pair editing identification of an intergenic mutation upstream of BUB1B as causative of PCS (MVA) syndrome.Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.
P2860
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P2860
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Direct production of mouse dis ...... ENs and oligodeoxynucleotides.
@ast
Direct production of mouse dis ...... ENs and oligodeoxynucleotides.
@en
type
label
Direct production of mouse dis ...... ENs and oligodeoxynucleotides.
@ast
Direct production of mouse dis ...... ENs and oligodeoxynucleotides.
@en
prefLabel
Direct production of mouse dis ...... ENs and oligodeoxynucleotides.
@ast
Direct production of mouse dis ...... ENs and oligodeoxynucleotides.
@en
P2093
P2860
P50
P356
P1476
Direct production of mouse dis ...... ENs and oligodeoxynucleotides.
@en
P2093
Benedikt Wefers
Melanie Meyer
Oskar Ortiz
Wolfgang Wurst
P2860
P304
P356
10.1073/PNAS.1218721110
P407
P577
2013-02-20T00:00:00Z