Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility.
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Rac and Rho GTPases in cancer cell motility controlATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundanceRegulation of RhoA-dependent ROCKII activation by Shp2Rho, ROCK and actomyosin contractility in metastasis as drug targetsCell polarity signaling in the plasticity of cancer cell invasivenessRho GTPase regulation by miRNAs and covalent modificationsThe RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin ContractilityReduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cellsTumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces.Plasticity in the macromolecular-scale causal networks of cell migrationInitial steps of metastasis: cell invasion and endothelial transmigrationSmurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cellsAn analysis toolbox to explore mesenchymal migration heterogeneity reveals adaptive switching between distinct modesPlasticity of cell migration: a multiscale tuning modelThe PAR proteins: fundamental players in animal cell polarization.The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition.p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling.Loss of ERα induces amoeboid-like migration of breast cancer cells by downregulating vinculin.Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under construction.CD47 regulates collagen I-induced cyclooxygenase-2 expression and intestinal epithelial cell migration.Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent.CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells.The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.TNFα-exposed bone marrow-derived mesenchymal stem cells promote locomotion of MDA-MB-231 breast cancer cells through transcriptional activation of CXCR3 ligand chemokines.RhoA phosphorylation induces Rac1 release from guanine dissociation inhibitor alpha and stimulation of vascular smooth muscle cell migrationRho/ROCK signaling in motility and metastasis of gastric cancerDia-interacting protein (DIP) imposes migratory plasticity in mDia2-dependent tumor cells in three-dimensional matrices.Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis.Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisitedPolarized regulation of glycogen synthase kinase-3β is important for glioma cell invasion.BMP-2 and TGFβ2 shared pathways regulate endocardial cell transformation.Localized Rho GTPase activation regulates RNA dynamics and compartmentalization in tumor cell protrusions.Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligaseFbx8 makes Arf6 refractory to function via ubiquitination.Stathmin activity influences sarcoma cell shape, motility, and metastatic potential.Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cellsUbiquitination of tumor necrosis factor receptor-associated factor 4 (TRAF4) by Smad ubiquitination regulatory factor 1 (Smurf1) regulates motility of breast epithelial and cancer cellsSmad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness.Transforming growth factor-beta signaling and ubiquitinators in cancer.Deregulation of Rho GTPases in cancer
P2860
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P2860
Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Smurf1 regulates tumor cell pl ...... d inhibition of contractility.
@ast
Smurf1 regulates tumor cell pl ...... d inhibition of contractility.
@en
type
label
Smurf1 regulates tumor cell pl ...... d inhibition of contractility.
@ast
Smurf1 regulates tumor cell pl ...... d inhibition of contractility.
@en
prefLabel
Smurf1 regulates tumor cell pl ...... d inhibition of contractility.
@ast
Smurf1 regulates tumor cell pl ...... d inhibition of contractility.
@en
P2860
P356
P1476
Smurf1 regulates tumor cell pl ...... d inhibition of contractility.
@en
P2093
Emmanuel Vial
Raquel Garcia-Medina
P2860
P356
10.1083/JCB.200605135
P407
P577
2006-12-26T00:00:00Z