about
CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathwaysRhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signalingApoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.Analysis of the composition, assembly kinetics and activity of native Apaf-1 apoptosomes.Molecular ordering of the caspase activation cascade initiated by the cytotoxic T lymphocyte/natural killer (CTL/NK) protease granzyme B.Caspase-dependent inactivation of proteasome function during programmed cell death in Drosophila and man.The cytotoxic lymphocyte protease, granzyme B, targets the cytoskeleton and perturbs microtubule polymerization dynamics.Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survivalMammalian EGF receptor activation by the rhomboid protease RHBDL2Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACEHuman and murine granzyme B exhibit divergent substrate preferencesApoptosomes: protease activation platforms to die from.Rhomboid intramembrane protease RHBDL4 triggers ER-export and non-canonical secretion of membrane-anchored TGFαNew lives for old: evolution of pseudoenzyme function illustrated by iRhoms.Inactive rhomboid proteins: New mechanisms with implications in health and disease.Role for CED-9 and Egl-1 as regulators of mitochondrial fission and fusion dynamics.Quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.Regulation of receptor tyrosine kinase ligand processingThe apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome CApoptosis: calling time on apoptosome activity.Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis.Search for Drosophila caspases bears fruit: STRICA enters the fray.Defying death: showing Bcl-2 the way home.Proteases, proteasomes and apoptosis: breaking Ub is hard to do.Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE.Proteomic and functional analysis identifies galectin-1 as a novel regulatory component of the cytotoxic granule machinery.iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.Caspases: Agents of Defense and DestructionCELL BIOLOGY: Double Knockout Blow for CaspasesiRhom2 and TNF: Partners or enemies?Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis
P50
Q24291679-106E938B-56C5-4264-AECE-11C90ADD6F9FQ24298141-23E1ED66-EF87-4922-B289-6E45AAA2429EQ24534641-C36B0927-1D9F-47B9-8727-1148F6C76D51Q30753875-318AEE5E-BA77-4257-8AA8-F229860EB31FQ30830747-E718ACCA-7C94-42AE-92ED-BB9ED0B933F1Q31132981-1A8169A0-8464-4625-B00E-0887E4533A4CQ33204112-BAA1825F-799B-4560-A590-1DDA3A671831Q33231728-0034D3F4-6345-4E45-B674-C24C45295FC7Q33423852-7D7FFE33-90D3-4C91-B693-272F49BD9C73Q34178493-D058338C-C73B-46FE-82EA-88421F79EB42Q34247194-AD2A3C4F-C876-4570-A57C-608F2C40B072Q36117776-220BDDE0-BFC3-4D2F-A004-6E59541BA9B9Q36440670-D3B88C41-5F09-4EC1-8101-477DA030D1D0Q36970233-BFC7CF56-45FD-48A0-A880-4391FE802EE6Q38025278-2517C918-C6FE-4368-8AC1-45D53CEF838CQ38885975-16F958EE-98DF-46B3-954D-1F4D1266FEE5Q40303654-5A081AB4-F089-464E-AB24-72246A391D8DQ41261009-5B80CB11-C0DC-49C3-8749-ADA6B1BD7E86Q41936018-8EF1C40A-9EDC-443A-8ED9-47A752F1D8D1Q41994915-9D186FD4-9282-4429-BEF1-3AEB89962CE4Q42100518-691939EE-6420-4F0F-93D9-8561052DF1ADQ43266147-6E4CD85C-FF6A-4AC9-AAB8-F7631F03EE7AQ43509147-7D6047FD-2035-43BA-B6F7-FF484A6CC551Q43691519-4141F2BA-A6C3-4807-B932-73873952A842Q44269166-A59CD201-C77F-403F-990E-0E1BC873C179Q46645036-556D9753-EBA0-4A8F-8A0B-508BD2AA1A5CQ47135385-B78D984A-F978-49DD-8444-2A9FF8820103Q47320158-2251E45F-4547-4AEC-93A8-079BF3B3F606Q55711821-0DDCAE5B-03AD-4CAC-89F2-AFA17EAC23B0Q60188556-E00A6A3D-92ED-4D4D-AC0D-785C17E5C236Q60188582-E387D967-DCDD-4991-86DE-F7F9E0BBCFC4Q90990804-05240606-EC57-4DC1-9581-2CBC1EB16787Q92524605-3AFD88BE-8CDE-41A3-A568-EC25DBFA35E7
P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Colin Adrain
@ast
Colin Adrain
@en
Colin Adrain
@es
Colin Adrain
@nl
Colin Adrain
@sl
type
label
Colin Adrain
@ast
Colin Adrain
@en
Colin Adrain
@es
Colin Adrain
@nl
Colin Adrain
@sl
prefLabel
Colin Adrain
@ast
Colin Adrain
@en
Colin Adrain
@es
Colin Adrain
@nl
Colin Adrain
@sl
P1053
I-6259-2013
P106
P1153
6603277425
P21
P31
P3829
P496
0000-0001-7597-4393