DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
about
A vertebrate gene, ticrr, is an essential checkpoint and replication regulatorNuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferaseSelective ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G ubiquitin-conjugating enzymes via the CRL4Cdt2 ubiquitin ligase complex.PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.Replication licensing and cancer--a fatal entanglement?Mechanisms to control rereplication and implications for cancer.The expanding regulatory universe of p53 in gastrointestinal cancerGenomic instability in cancer.Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4BCell cycle control in the early embryonic development of aquatic animal speciesUSP37 deubiquitinates Cdt1 and contributes to regulate DNA replicationRegulation of TGF-β signaling, exit from the cell cycle, and cellular migration through cullin cross-regulation: SCF-FBXO11 turns off CRL4-Cdt2.CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cellsCRL4Cdt2: master coordinator of cell cycle progression and genome stabilityTranscriptional regulation of an evolutionary conserved intergenic region of CDT2-INTS7.Microarray analysis of RNA extracted from formalin-fixed, paraffin-embedded and matched fresh-frozen ovarian adenocarcinomas.Genome-wide microarray evidence that 8-cell human blastomeres over-express cell cycle drivers and under-express checkpoints.Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review.Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas.The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells.Role of the Na ⁺/K ⁺/2Cl⁻ cotransporter NKCC1 in cell cycle progression in human esophageal squamous cell carcinoma.Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.Patterns of gene expression in Drosophila InsP3 receptor mutant larvae reveal a role for InsP3 signaling in carbohydrate and energy metabolism.Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R.Thymine DNA glycosylase is a CRL4Cdt2 substrate.Tbl3 regulates cell cycle length during zebrafish development.Identification of novel targets for breast cancer by exploring gene switches on a genome scale.CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs.The stress phenotype makes cancer cells addicted to CDT2, a substrate receptor of the CRL4 ubiquitin ligase.Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.Checkpoint kinase ATR phosphorylates Cdt2, a substrate receptor of CRL4 ubiquitin ligase, and promotes the degradation of Cdt1 following UV irradiation.Rereplication in emi1-deficient zebrafish embryos occurs through a Cdh1-mediated pathway.Replication licensing and the DNA damage checkpoint.Non-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.Identification of male gametogenesis expressed genes from the scallop Nodipecten subnodosus by suppressive subtraction hybridization and pyrosequencing.Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligaseImplications of microRNAs in colorectal cancer development, diagnosis, prognosis, and therapeutics.Mitotic UV irradiation induces a DNA replication-licensing defect that potentiates G1 arrest response.
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DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@ast
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@en
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@en-gb
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@nl
type
label
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@ast
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@en
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@en-gb
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@nl
prefLabel
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@ast
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@en
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@en-gb
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@nl
P2093
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P3181
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DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint
@en
P2093
Adam Amsterdam
Alessandra Ianari
Jacqueline A Lees
Jennifer L Shepard
Nancy Hopkins
P2860
P304
P3181
P356
10.1101/GAD.1482106
P407
P577
2006-11-03T00:00:00Z