The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system.
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Sumoylation in Synaptic Function and DysfunctionThe ubiquitin proteasomal system: a potential target for the management of Alzheimer's diseaseIt Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer DiseaseAdaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbationsTau Oligomers: The Toxic Player at Synapses in Alzheimer's DiseaseMechanisms of protein seeding in neurodegenerative diseasesCritical role of acetylation in tau-mediated neurodegeneration and cognitive deficitsDysregulation of Ubiquitin-Proteasome System in Neurodegenerative DiseasesAnalyzing dendritic spine pathology in Alzheimer's disease: problems and opportunitiesTau-mediated synaptic damage in Alzheimer's diseaseStudying synapses in human brain with array tomography and electron microscopyTau protein is essential for stress-induced brain pathologyTau association with synaptic vesicles causes presynaptic dysfunction.The intersection of amyloid beta and tau at synapses in Alzheimer's diseaseFrequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease.Characterization of tau oligomeric seeds in progressive supranuclear palsy.Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling.The calcium-binding protein EFhd2 modulates synapse formation in vitro and is linked to human dementia.Oligomer formation of tau protein hyperphosphorylated in cells.Progress in Alzheimer's disease research in the last year.Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathyRescue of tau-induced synaptic transmission pathology by paclitaxel.Isolation and characterization of antibody fragments selective for toxic oligomeric tauDegradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Passive immunotherapy of tauopathy targeting pSer413-tau: a pilot study in mice.Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's diseasePost-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapseSynaptic activity and Alzheimer's disease: a critical update.Administration of NaHS Attenuates Footshock-Induced Pathologies and Emotional and Cognitive Dysfunction in Triple Transgenic Alzheimer's Mice.Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicitySynaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases.Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathiesThe importance of tau phosphorylation for neurodegenerative diseasesDissecting phenotypic traits linked to human resilience to Alzheimer's pathology.Synaptic alterations in the rTg4510 mouse model of tauopathy.Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease.Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration.Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease.Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage.Protein Quality Control by Molecular Chaperones in Neurodegeneration.
P2860
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P2860
The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
The synaptic accumulation of h ...... e ubiquitin-proteasome system.
@ast
The synaptic accumulation of h ...... e ubiquitin-proteasome system.
@en
type
label
The synaptic accumulation of h ...... e ubiquitin-proteasome system.
@ast
The synaptic accumulation of h ...... e ubiquitin-proteasome system.
@en
prefLabel
The synaptic accumulation of h ...... e ubiquitin-proteasome system.
@ast
The synaptic accumulation of h ...... e ubiquitin-proteasome system.
@en
P2860
P50
P1476
The synaptic accumulation of h ...... e ubiquitin-proteasome system.
@en
P2093
Matthew P Frosch
Tadafumi Hashimoto
P2860
P304
P356
10.1016/J.AJPATH.2012.06.033
P407
P577
2012-08-04T00:00:00Z