Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation
about
Antibacterial Discovery and Development: From Gene to Product and BackSynthetic biology to access and expand nature's chemical diversityEngineering of Streptomyces platensis MA7339 for overproduction of platencin and congeners.Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporusMetabolic engineering for the production of natural products.Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator.Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027.Expression of the platencin biosynthetic gene cluster in heterologous hosts yielding new platencin congeners.An engineered strong promoter for streptomycetesMedium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J.Synthetic RNA Silencing of Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2).A sea of biosynthesis: marine natural products meet the molecular age.Regulation of the AbrA1/A2 two-component system in Streptomyces coelicolor and the potential of its deletion strain as a heterologous host for antibiotic production.Toward a Cancer Drug of Fungal OriginOverproduction of lactimidomycin by cross-overexpression of genes encoding Streptomyces antibiotic regulatory proteins.Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.Platensimycin and platencin: Inspirations for chemistry, biology, enzymology, and medicine.Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites.Strain improvement in actinomycetes in the postgenomic era.Natural products and Pharma 2011: strategic changes spur new opportunities.Platensimycin and platencin: promising antibiotics for future application in human medicine.Synthetic biological approaches to natural product biosynthesis.Recent advances in recombinant protein expression by Corynebacterium, Brevibacterium, and Streptomyces: from transcription and translation regulation to secretion pathway selection.Isolation and structural elucidation of glucoside congeners of platencin from Streptomyces platensis SB12600.Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.Engineering microbial hosts for production of bacterial natural productsActinoplanes teichomyceticus ATCC 31121 as a cell factory for producing teicoplanin.Engineering of N-acetylglucosamine metabolism for improved antibiotic production in Streptomyces coelicolor A3(2) and an unsuspected role of NagA in glucosamine metabolism.Insect-specific production of new GameXPeptides in photorhabdus luminescens TTO1, widespread natural products in entomopathogenic bacteria.Transcriptional regulation and increased production of asukamycin in engineered Streptomyces nodosus subsp. asukaensis strains.A new cyclododeca[d]oxazole derivative from Streptomyces spp. CIBYL1.Direct Involvement of the Master Nitrogen Metabolism Regulator GlnR in Antibiotic Biosynthesis in Streptomyces.The pathway-specific regulatory genes, tei15* and tei16*, are the master switches of teicoplanin production in Actinoplanes teichomyceticus.Genetic engineering of Streptomyces bingchenggensis to produce milbemycins A3/A4 as main components and eliminate the biosynthesis of nanchangmycin.Strain improvement by combined UV mutagenesis and ribosome engineering and subsequent fermentation optimization for enhanced 6'-deoxy-bleomycin Z production.Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus.Characterization of three pathway-specific regulators for high production of monensin in Streptomyces cinnamonensis.DasR positively controls monensin production at two-level regulation in Streptomyces cinnamonensis.Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum.Characterization of novel DeoR-family member from the Streptomyces ahygroscopicus strain CK-15 that acts as a repressor of morphological development.
P2860
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P2860
Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
@zh-sg
2010年學術文章
@yue
2010年學術文章
@zh
2010年學術文章
@zh-hant
name
Improvement of secondary metab ...... anipulating pathway regulation
@ast
Improvement of secondary metab ...... anipulating pathway regulation
@en
type
label
Improvement of secondary metab ...... anipulating pathway regulation
@ast
Improvement of secondary metab ...... anipulating pathway regulation
@en
prefLabel
Improvement of secondary metab ...... anipulating pathway regulation
@ast
Improvement of secondary metab ...... anipulating pathway regulation
@en
P2093
P2860
P1476
Improvement of secondary metab ...... anipulating pathway regulation
@en
P2093
Michael J Smanski
Yihua Chen
P2860
P2888
P356
10.1007/S00253-009-2428-3
P407
P577
2010-01-21T00:00:00Z