Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning
about
CryoEM structures of two spliceosomal complexes: starter and dessert at the spliceosome feastFunctional roles of DExD/H-box RNA helicases in Pre-mRNA splicingRNA helicases in splicingSplicing fidelity: DEAD/H-box ATPases as molecular clocksRNA helicase proteins as chaperones and remodelersThe architecture of the spliceosomal U4/U6.U5 tri-snRNP.Structural Basis of Brr2-Prp8 Interactions and Implications for U5 snRNP Biogenesis and the Spliceosome Active SiteInhibition of RNA helicase Brr2 by the C-terminal tail of the spliceosomal protein Prp8Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly.Splicing proofreading at 5' splice sites by ATPase Prp28p.Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.PRPF8 defects cause missplicing in myeloid malignancies.Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding.Limited portability of G-patch domains in regulators of the Prp43 RNA helicase required for pre-mRNA splicing and ribosomal RNA maturation in Saccharomyces cerevisiae.BRR2a Affects Flowering Time via FLC SplicingSpliceosome activation: U4 is the path, stem I is the goal, and Prp8 is the keeper. Let's cheer for the ATPase Brr2!Retinitis Pigmentosa Mutations in Bad Response to Refrigeration 2 (Brr2) Impair ATPase and Helicase ActivitySubstrate-assisted mechanism of RNP disruption by the spliceosomal Brr2 RNA helicase.A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex.Sad1 counteracts Brr2-mediated dissociation of U4/U6.U5 in tri-snRNP homeostasis.The spliceosome: disorder and dynamics defined.RNA and Proteins: Mutual Respect.Structural studies of the spliceosome: zooming into the heart of the machine.Novel regulatory principles of the spliceosomal Brr2 RNA helicase and links to retinal disease in humans.A DEAD box RNA helicase is critical for pre-mRNA splicing, cold-responsive gene regulation, and cold tolerance in Arabidopsis.Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution.Functions and regulation of the Brr2 RNA helicase during splicing.Assembly and dynamics of the U4/U6 di-snRNP by single-molecule FRET.Cwc21p promotes the second step conformation of the spliceosome and modulates 3' splice site selection.The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activation.The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase.Protein localisation by electron microscopy reveals the architecture of the yeast spliceosomal B complex.Interplay of cis- and trans-regulatory mechanisms in the spliceosomal RNA helicase Brr2.Mechanistic insights into precursor messenger RNA splicing by the spliceosome.Therapeutic Applications of Targeted Alternative Splicing to Cancer Treatment.Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2.Retinitis pigmentosa mutations of SNRNP200 enhance cryptic splice-site recognition.Life and Death of mRNA Molecules in Entamoeba histolytica.
P2860
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P2860
Brr2p-mediated conformational rearrangements in the spliceosome during activation and substrate repositioning
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Brr2p-mediated conformational ...... on and substrate repositioning
@ast
Brr2p-mediated conformational ...... on and substrate repositioning
@en
type
label
Brr2p-mediated conformational ...... on and substrate repositioning
@ast
Brr2p-mediated conformational ...... on and substrate repositioning
@en
prefLabel
Brr2p-mediated conformational ...... on and substrate repositioning
@ast
Brr2p-mediated conformational ...... on and substrate repositioning
@en
P2860
P356
P1433
P1476
Brr2p-mediated conformational ...... on and substrate repositioning
@en
P2093
Daniela Hahn
Jean D Beggs
P2860
P304
P356
10.1101/GAD.199307.112
P577
2012-11-01T00:00:00Z