RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1
about
Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break RepairAn RNF168 fragment defective for focal accumulation at DNA damage is proficient for inhibition of homologous recombination in BRCA1 deficient cells.53BP1 promotes microhomology-mediated end-joining in G1-phase cells.DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining.Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining.USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress.microRNA-7 suppresses the invasive potential of breast cancer cells and sensitizes cells to DNA damages by targeting histone methyltransferase SET8Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombinationA PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation.DNA damage sensing by the ATM and ATR kinases.Retroviral insertional mutagenesis implicates E3 ubiquitin ligase RNF168 in the control of cell proliferation and survival.53BP1 fosters fidelity of homology-directed DNA repair.Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair.The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.Regulation of Single-Strand Annealing and its Role in Genome Maintenance.Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.PRPF8 is important for BRCA1-mediated homologous recombination.USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.Repair of DNA double-strand breaks by mammalian alternative end-joining pathways.RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair
P2860
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P2860
RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
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name
RING finger nuclear factor RNF ...... er susceptibility factor BRCA1
@ast
RING finger nuclear factor RNF ...... er susceptibility factor BRCA1
@en
type
label
RING finger nuclear factor RNF ...... er susceptibility factor BRCA1
@ast
RING finger nuclear factor RNF ...... er susceptibility factor BRCA1
@en
prefLabel
RING finger nuclear factor RNF ...... er susceptibility factor BRCA1
@ast
RING finger nuclear factor RNF ...... er susceptibility factor BRCA1
@en
P2093
P2860
P356
P1476
RING finger nuclear factor RNF ...... er susceptibility factor BRCA1
@en
P2093
Amanda Gunn
André Nussenzweig
Anita Cheng
Corentin Laulier
Davide F Robbiani
Jeremy M Stark
Meilen C Muñoz
P2860
P304
40618-40628
P356
10.1074/JBC.M112.410951
P407
P577
2012-10-10T00:00:00Z