Development of α-helical calpain probes by mimicking a natural protein-protein interaction.
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Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled PeptidesConstraining cyclic peptides to mimic protein structure motifs.Comparative α-helicity of cyclic pentapeptides in water.Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy.Helix Nucleation by the Smallest Known α-Helix in Water.Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target.Stapled Voltage-Gated Calcium Channel (CaV) α-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV FunctionSynthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers.Convergent diversity-oriented side-chain macrocyclization scan for unprotected polypeptides.Tightening up the structure, lighting up the pathway: Application of molecular constraints and light to manipulate protein folding, self-assembly and function.Enzyme-catalyzed macrocyclization of long unprotected peptides.Library construction, selection and modification strategies to generate therapeutic peptide-based modulators of protein-protein interactions.Designer macrocyclic organo-peptide hybrids inhibit the interaction between p53 and HDM2/X by accommodating a functional α-helix.Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-AlkylationConformational Restriction of Peptides Using Dithiol Bis-AlkylationAcetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling.Design of Potent and Proteolytically Stable Oxyntomodulin Analogs.A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling.Infrared and Fluorescence Assessment of Protein Dynamics: From Folding to Function.Assessment of local friction in protein folding dynamics using a helix cross-linker.How quickly can a β-hairpin fold from its transition state?Thioamide-based fluorescent protease sensorsConverting disulfide bridges in native peptides to stable methylene thioacetals.An updated patent review of calpain inhibitors (2012 - 2014).Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Chemical Protein Modification through Cysteine.Review stapling peptides using cysteine crosslinking.The Cysteine S-Alkylation Reaction as a Synthetic Method to Covalently Modify Peptide Sequences.Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides.Calpain research for drug discovery: challenges and potential.Thioether-Derived Macrocycle for Peptide Secondary Structure Fixation.Intramolecular Hydrogen Bonding Involving Organic Fluorine: NMR Investigations Corroborated by DFT-Based Theoretical Calculations.α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells.Receptor-templated stapling of intrinsically disordered peptide ligands.Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling.Stapling monomeric GCN4 peptides allows for DNA binding and enhanced cellular uptake.Synthesis of bioactive and stabilized cyclic peptides by macrocyclization using C(sp3)-H activation.New peptide architectures through C-H activation stapling between tryptophan-phenylalanine/tyrosine residuesHydrocarbon constrained peptides - understanding preorganisation and binding affinity.Double quick, double click reversible peptide "stapling".
P2860
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P2860
Development of α-helical calpain probes by mimicking a natural protein-protein interaction.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Development of α-helical calpa ...... l protein-protein interaction.
@ast
Development of α-helical calpa ...... l protein-protein interaction.
@en
type
label
Development of α-helical calpa ...... l protein-protein interaction.
@ast
Development of α-helical calpa ...... l protein-protein interaction.
@en
prefLabel
Development of α-helical calpa ...... l protein-protein interaction.
@ast
Development of α-helical calpa ...... l protein-protein interaction.
@en
P2093
P2860
P356
P1476
Development of α-helical calpa ...... l protein-protein interaction.
@en
P2093
Doron C Greenbaum
Kristin E Low
Nataline Meinhardt
Peter L Davies
Swapnil Kulkarni
Xiaozhen Hu
P2860
P304
17704-17713
P356
10.1021/JA307599Z
P407
P577
2012-10-11T00:00:00Z