Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors - Test2 - elhamkhani - TriplyDB

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors

http://www.wikidata.org/entity/Q36637356

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Structural Mechanisms and Drug Discovery Prospects of Rho GTPases Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy Approaches of targeting Rho GTPases in cancer drug discovery Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease Vav family exchange factors: an integrated regulatory and functional view Rational design of small molecule inhibitors targeting the Ras GEF, SOS1.Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex A Pan-GTPase Inhibitor as a Molecular Probe Cyanidin-3-o-glucoside directly binds to ERα36 and inhibits EGFR-positive triple-negative breast cancer Cell-matrix adhesion and cell-cell adhesion differentially control basal myosin oscillation and Drosophila egg chamber elongation.Cellular mechanisms of tissue fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription.Targeting Rho-GTPases in immune cell migration and inflammation.Targeting GTPases in Parkinson's disease: comparison to the historic path of kinase drug discovery and perspectives Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice.ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells.G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.CD147 promotes cell motility via upregulation of p190-B RhoGAP in hepatocellular carcinoma Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting.Annexin A1 restores Aβ1-42 -induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway.Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation.RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells.Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD).The lens actin filament cytoskeleton: Diverse structures for complex functions.Rho GTPases: Anti- or pro-neoplastic targets?The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration.Genomic landscape of gastric cancer: molecular classification and potential targets.Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.Rho GTPases and cancer.ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1.Gα13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.Kctd13 deletion reduces synaptic transmission via increased RhoA.Transforming growth factor-β enhances Rho-kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1.RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases.A High-Throughput Assay for Rho Guanine Nucleotide Exchange Factors Based on the Transcreener GDP Assay.Loopβ3αC plays an important role in the structure and function of isocitrate dehydrogenase kinase/phosphatase.A biochemical network controlling basal myosin oscillation.Leukaemia-associated Rho guanine nucleotide exchange factor (LARG) plays an agonist specific role in platelet function through RhoA activation.Proposed Molecular and miRNA Classification of Gastric Cancer.

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P2860

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors

http://www.wikidata.org/entity/Q36637356

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Small-molecule inhibitors targ ...... ne nucleotide exchange factors

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Chris R Evelyn

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Fillipo Marchioni

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Matthew Wortman

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Nisha Sipes

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William Seibel

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Xuan Zhou

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Xun Shang

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Yi Zheng

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P2860

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho

Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Rho GTPases: biochemistry and biology

Rho GTPases in cell biology

Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho

Dbl family guanine nucleotide exchange factors

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product

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