The Wnt signaling pathway: aging gracefully as a protectionist? - Test2 - elhamkhani - TriplyDB

The Wnt signaling pathway: aging gracefully as a protectionist?

The Wnt signaling pathway: aging gracefully as a protectionist?

http://www.wikidata.org/entity/Q36728844

about

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6 Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR Erythropoietin and diabetes mellitus Stem cell guidance through the mechanistic target of rapamycin FoxO Transcription Factors and Regenerative Pathways in Diabetes Mellitus Erythropoietin: new directions for the nervous system The age-related changes in cartilage and osteoarthritis Targeting disease through novel pathways of apoptosis and autophagy Uncovering novel actors in astrocyte-neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair The regulation and deregulation of Wnt signaling by PARK genes in health and disease Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin Erythropoietin and mTOR: A "One-Two Punch" for Aging-Related Disorders Accompanied by Enhanced Life Expectancy New Insights for Oxidative Stress and Diabetes Mellitus Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease CCN4 regulates vascular smooth muscle cell migration and proliferation A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection An integrative network algorithm identifies age-associated differential methylation interactome hotspots targeting stem-cell differentiation pathways A common biological mechanism in cancer and Alzheimer's disease?Oxidative stress: Biomarkers and novel therapeutic pathways.New strategies for Alzheimer's disease and cognitive impairment.Diabetes mellitus: channeling care through cellular discovery The "O" class: crafting clinical care with FoxO transcription factors.Wnt1, FoxO3a, and NF-kappaB oversee microglial integrity and activation during oxidant stress.Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways.WISP1: Clinical insights for a proliferative and restorative member of the CCN family The role of lipid peroxidation products and oxidative stress in activation of the canonical wingless-type MMTV integration site (WNT) pathway in a rat model of diabetic retinopathy Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction.Novel avenues of drug discovery and biomarkers for diabetes mellitus.Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae.EPO relies upon novel signaling of Wnt1 that requires Akt1, FoxO3a, GSK-3β, and β-catenin to foster vascular integrity during experimental diabetes.Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress.Mammalian target of rapamycin: hitting the bull's-eye for neurological disorders.A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes.Pathogen-specific TLR2 protein activation programs macrophages to induce Wnt-beta-catenin signaling.Neuroprotective effect of fasudil on inflammation through PI3K/Akt and Wnt/β-catenin dependent pathways in a mice model of Parkinson's disease.Translating cell survival and cell longevity into treatment strategies with SIRT1 Erythropoietin and Wnt1 govern pathways of mTOR, Apaf-1, and XIAP in inflammatory microglia.Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL.WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy.

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The Wnt signaling pathway: aging gracefully as a protectionist?

http://www.wikidata.org/entity/Q36728844

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2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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The Wnt signaling pathway: aging gracefully as a protectionist?

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J.PHARMTHERA.2008.01.004

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Pharmacology & Therapeutics

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The Wnt signaling pathway: aging gracefully as a protectionist?

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Faqi Li

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Kenneth Maiese

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Yan Chen Shang

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Zhao Zhong Chong

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P2860

A new secreted protein that binds to Wnt proteins and inhibits their activities

Inhibition of adipogenesis by Wnt signaling

LDL-receptor-related proteins in Wnt signal transduction

Up-regulation of WNT-4 signaling and dosage-sensitive sex reversal in humans.

Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iepsilon

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.

Wnt5a-mediated non-canonical Wnt signalling regulates human endothelial cell proliferation and migration

Wnt signaling protects 3T3-L1 preadipocytes from apoptosis through induction of insulin-like growth factors

Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

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58-81

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10.1016/J.PHARMTHERA.2008.01.004

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1

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