Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains. - Test2 - elhamkhani - TriplyDB

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.

http://www.wikidata.org/entity/Q36781872

about

The analysis of clonal expansions in normal and autoimmune B cell repertoires HIV broadly neutralizing antibody targets Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies High-Throughput Sequencing-Based Immune Repertoire Study during Infectious Disease Accurate and predictive antibody repertoire profiling by molecular amplification fingerprinting Consistency of VDJ Rearrangement and Substitution Parameters Enables Accurate B Cell Receptor Sequence Annotation Quantifying evolutionary constraints on B-cell affinity maturation Assigning and visualizing germline genes in antibody repertoires Computational tools for epitope vaccine design and evaluation Darwin and Fisher meet at biotech: on the potential of computational molecular evolution in industry.Generation of Long-Lived Bone Marrow Plasma Cells Secreting Antibodies Specific for the HIV-1 gp41 Membrane-Proximal External Region in the Absence of Polyreactivity.Clonify: unseeded antibody lineage assignment from next-generation sequencing data Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization The promise and challenge of high-throughput sequencing of the antibody repertoire.The Antibody Germline/Maturation Hypothesis, Elicitation of Broadly Neutralizing Antibodies Against HIV-1 and Cord Blood IgM Repertoires Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis High-throughput sequencing of human immunoglobulin variable regions with subtype identification.Quantitative assessment of the robustness of next-generation sequencing of antibody variable gene repertoires from immunized mice Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity.Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo.Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.The application of next generation sequencing to the understanding of antibody repertoires.Extensive recombination due to heteroduplexes generates large amounts of artificial gene fragments during PCR Isolation and characterization of antigen-specific alpaca (Lama pacos) VHH antibodies by biopanning followed by high-throughput sequencing.Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8 Rhesus Macaque B-Cell Responses to an HIV-1 Trimer Vaccine Revealed by Unbiased Longitudinal Repertoire Analysis.Identification of highly selective MMP-14 inhibitory Fabs by deep sequencing.Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1.Hierarchical Clustering Can Identify B Cell Clones with High Confidence in Ig Repertoire Sequencing Data.Conformational Epitope-Specific Broadly Neutralizing Plasma Antibodies Obtained from an HIV-1 Clade C-Infected Elite Neutralizer Mediate Autologous Virus Escape through Mutations in the V1 Loop.Statistical inference of a convergent antibody repertoire response to influenza vaccine Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding.Selection of therapeutic H5N1 monoclonal antibodies following IgVH repertoire analysis in mice.Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts.SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts.Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers.

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Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains.

http://www.wikidata.org/entity/Q36781872

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

@zh-cn

name

Mining the antibodyome for HIV ...... pairing of heavy/light chains.

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Mining the antibodyome for HIV ...... pairing of heavy/light chains.

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Mining the antibodyome for HIV ...... pairing of heavy/light chains.

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Proceedings of the National Academy of Sciences of the United States of America

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Mining the antibodyome for HIV ...... pairing of heavy/light chains.

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Baoshan Zhang

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Gabriel Lu

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Gilad Ofek

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Jiang Zhu

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Joshua Eudailey

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Julie Blinn

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Krisha McKee

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Krissey E Lloyd

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Lawrence Shapiro

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P2860

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies

Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target

Broad neutralization coverage of HIV by multiple highly potent antibodies

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

Sequencing antibody repertoires: the next generation.

454 antibody sequencing - error characterization and correction.

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6470-6475

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16

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NISC Comparative Sequencing Program

James C Mullikin

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2013-03-27T00:00:00Z

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236087738

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23536288

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