Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
about
Zwilch, a new component of the ZW10/ROD complex required for kinetochore functionsFunctional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interferenceStructural analysis reveals features of the spindle checkpoint kinase Bub1-kinetochore subunit Knl1 interactionNEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signalingDynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome lossBubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint controlThe PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formationCheckpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complexIdentification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulationAnalysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated proteinMicrotubule-dependent changes in assembly of microtubule motor proteins and mitotic spindle checkpoint proteins at PtK1 kinetochoresAblation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does notGene silencing of CENP-E by small interfering RNA in HeLa cells leads to missegregation of chromosomes after a mitotic delayLethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesisMammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpointsA new view of the spindle checkpointCheckpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cellsSpindle checkpoint protein Bub1 is required for kinetochore localization of Mad1, Mad2, Bub3, and CENP-E, independently of its kinase activitySpindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochoreHuman MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochoresHURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.DNA Damage: A Main Determinant of Vascular AgingOTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic KinasesDynein/Dynactin-mediated transport of kinetochore components off kinetochores and onto spindle poles induced by nordihydroguaiaretic acidThe spindle checkpoint of the yeast Saccharomyces cerevisiae requires kinetochore function and maps to the CBF3 domain.The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control.The roles of MAD1, MAD2 and MAD3 in meiotic progression and the segregation of nonexchange chromosomes.MAD3 encodes a novel component of the spindle checkpoint which interacts with Bub3p, Cdc20p, and Mad2p.Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progressionCTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding SitesFarnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubulesThe mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteinsAurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochoresCentromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)atedWD repeat-containing mitotic checkpoint proteins act as transcriptional repressors during interphaseAnalysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinome
P2860
Q24299625-A9DF78FE-435D-4423-8EA7-B601E77B0DF3Q24300469-D4779D04-1ABB-4266-AD4C-1131FF4224F4Q24305233-525031C4-77B4-452E-BC40-5E366812A235Q24310671-BACBA914-0C33-43AD-9C57-A00BD3780E9DQ24312788-20004EDE-08DB-4F79-BC8E-6D23CD6574FCQ24316292-5B4959B3-B94C-43C5-BE0C-37C01911141EQ24320279-D85828A7-FE2E-4BC9-94CD-BAE3B8A2B881Q24338299-3D7E1E20-5A34-4EDF-9CCF-46353660303BQ24545999-1C3EF4C8-5557-4D4C-85FD-568B67D0BAFBQ24548359-CE12BE85-6186-426E-BBF6-8516A7A79924Q24550894-760B67F1-12E4-422B-92E8-9A4FF8CB8073Q24555066-4A4E8923-0C58-4C9D-87EC-354AE46FDE8BQ24555706-417E9884-9660-400A-BE2D-7B40AEFE7B52Q24556579-1CE345AC-2BD0-4CB4-A783-6A691F39F717Q24561583-B456C2C6-8795-4D77-BCB1-CA0ED69EBE77Q24564215-30FB1C86-2EE0-4A6D-A0ED-7768DFFFB460Q24600680-FE48C434-C1CF-4FE0-B1D7-EE22EDD9DC88Q24635263-D77BC1B4-5BE5-4712-9A09-BB90720C1B11Q24670048-95FE3D80-3631-45C2-8FAB-E1F28EA58DACQ24670095-B40A100F-659C-4F27-9B2E-1A62C692536BQ24673713-025A49D6-6F63-4291-9BBD-C09126EC2BF8Q24679269-91B6174F-78A8-4178-999E-80E87614B174Q24682934-4EDCA484-26C3-4441-A002-71982F220ECCQ24682987-1F8CBBEB-A82B-45E0-8815-78D55324AEA7Q24683651-1FE539DC-3991-4DB5-8B13-594A6172BF79Q26746962-3ECD31DD-4F69-4F74-8108-D7948D3CF1E0Q27313731-C30C0A63-05E5-4C3B-A9E9-1F7BB7C9B104Q27437627-8C875265-57EA-4D1D-96B0-0A059C8B2EE5Q27933938-33401045-0E3F-4672-8597-6A162D3E6882Q27934353-760FA205-43AD-4C53-841A-89059D6DB6B7Q27935576-D27EC2AB-00F6-4A51-98CB-2998A0AF5B19Q27935794-D5DA60FF-82D7-49E1-9B07-FE1D52804D69Q28115063-DCC78608-6182-464B-96DB-FC82909DC83DQ28115322-D6A16B05-5B06-48DD-B27B-BA7F298F844FQ28138265-013FA450-F48F-4EB4-812F-CC805A9F0E75Q28188970-5B9A035C-891C-4455-A087-96452D838487Q28201606-6B152B27-0AC4-46BD-9885-1CF67CEDDA7AQ28217564-B20C7BF7-A29C-47FD-B9C6-F6549B059648Q28283832-3FA3FDC4-693F-4928-8FD5-C23E8C465D51Q28476427-4124D46B-7E3C-4E42-978D-5F8DFEF86988
P2860
Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
description
1999 nî lūn-bûn
@nan
1999 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@ast
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@en
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@en-gb
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@nl
type
label
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@ast
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@en
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@en-gb
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@nl
prefLabel
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@ast
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@en
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@en-gb
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@nl
P2093
P2860
P921
P3181
P356
P1476
Human BUBR1 is a mitotic check ...... es and binds the cyclosome/APC
@en
P2093
J C Hittle
S A Jablonski
P2860
P304
P3181
P356
10.1083/JCB.146.5.941
P407
P577
1999-09-01T00:00:00Z