Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses - Test2 - elhamkhani - TriplyDB

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

http://www.wikidata.org/entity/Q36916561

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Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin Sestrins at the crossroad between stress and aging Vitamin D3 up-regulated protein 1(VDUP1) is regulated by FOXO3A and miR-17-5p at the transcriptional and post-transcriptional levels, respectively, in senescent fibroblasts α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum The role of tumor suppressor p53 in the antioxidant defense and metabolism Reduction of Cysteine Sulfinic Acid in Peroxiredoxin by Sulfiredoxin Proceeds Directly through a Sulfinic Phosphoryl Ester Intermediate Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes Emerging therapies in traumatic brain injury Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains Hepatoprotective role of Sestrin2 against chronic ER stress Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss Neuronal activity regulates astrocytic Nrf2 signaling Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity How Nox2-containing NADPH oxidase affects cortical circuits in the NMDA receptor antagonist model of schizophrenia.Activation of dopamine D1 receptors blocks phencyclidine-induced neurotoxicity by enhancing N-methyl-D-aspartate receptor-mediated synaptic strength Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease.A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus.Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway.The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis Upregulation of sestrins protect atriums against oxidative damage and fibrosis in human and experimental atrial fibrillation.New Insight Into Metformin Action: Regulation of ChREBP and FOXO1 Activities in Endothelial Cells Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy Nuclear factor of activated T-cells isoform c4 (NFATc4/NFAT3) as a mediator of antiapoptotic transcription in NMDA receptor-stimulated cortical neurons Downregulation of Kv4.2 channels mediated by NR2B-containing NMDA receptors in cultured hippocampal neurons Essential involvement of the NMDA receptor in ethanol preconditioning-dependent neuroprotection from amyloid-betain vitro.Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling mechanisms.Modulation of GABAergic and glutamatergic transmission by ethanol in the developing neocortex: an in vitro test of the excessive inhibition hypothesis of fetal alcohol spectrum disorder.Thioredoxin-interacting protein (Txnip) gene expression: sensing oxidative phosphorylation status and glycolytic rate.Preventing Ca2+-mediated nitrosative stress in neurodegenerative diseases: possible pharmacological strategies.Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival.The neuroprotective effect of Klotho is mediated via regulation of members of the redox system.Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease.Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.

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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

http://www.wikidata.org/entity/Q36916561

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2008年論文

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2008年论文

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2008年论文

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name

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

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Nature Neuroscience

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Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

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Bruce A Yankner

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Chrysanthy Ikonomidou

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Frédéric Léveillé

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Grahame McKenzie

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Henrik H Hansen

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Jill Fowler

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Kelly A Dakin

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Marc-Andre Martel

http://www.w3.org/2001/XMLSchema#string

Marco Sifringer

http://www.w3.org/2001/XMLSchema#string

Marie Craigon

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine

Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains

Reactions of yeast thioredoxin peroxidases I and II with hydrogen peroxide and peroxynitrite: rate constants by competitive kinetics.

ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin.

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

Structure, mechanism and regulation of peroxiredoxins

The chemical biology of clinically tolerated NMDA receptor antagonists

Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein

Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists

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P304

476-487

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10.1038/NN2071

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P433

4

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P478

11

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Giles E. Hardingham

Francesc X Soriano

Karen Horsburgh

P577

2008-03-23T00:00:00Z

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230764502

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18344994

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2556874

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