about
Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegenerationTranscriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxinCellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signalsAdaptive regulation of the brain's antioxidant defences by neurons and astrocytesSynGAP isoforms exert opposing effects on synaptic strengthNeuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicityHypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptorsActivin/Nodal inhibition alone accelerates highly efficient neural conversion from human embryonic stem cells and imposes a caudal positional identity.Functional assessment of the NMDA receptor variant GluN2A R586K.Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism.Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsySynaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders.Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neuronsIonotropic GABA and glycine receptor subunit composition in human pluripotent stem cell-derived excitatory cortical neurones.Coupling of the NMDA receptor to neuroprotective and neurodestructive events.The Yin and Yang of NMDA receptor signalling.Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ SignalingSelective dendritic susceptibility to bioenergetic, excitotoxic and redox perturbations in cortical neurons.The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults.Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonistInvestigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis.Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition.Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response.Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1.Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytesSynaptic NMDA receptor activity boosts intrinsic antioxidant defensesThe dichotomy of NMDA receptor signaling.NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neuronsRecovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposureEvidence for evolutionary divergence of activity-dependent gene expression in developing neuronsPhysiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells.Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons.CNS peroxiredoxins and their regulation in health and disease.The influence of synaptic activity on neuronal health.Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegenerationInfluence of GluN2 subunit identity on NMDA receptor function.Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning.CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons.
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description
biochemicus
@nl
biochemist
@en
name
Giles E. Hardingham
@ast
Giles E. Hardingham
@en
Giles E. Hardingham
@es
Giles E. Hardingham
@nl
type
label
Giles E. Hardingham
@ast
Giles E. Hardingham
@en
Giles E. Hardingham
@es
Giles E. Hardingham
@nl
prefLabel
Giles E. Hardingham
@ast
Giles E. Hardingham
@en
Giles E. Hardingham
@es
Giles E. Hardingham
@nl
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P166
P21
P31
P496
0000-0002-7629-5314