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Targeting DNA Replication Stress for Cancer TherapyTrial Watch: Targeting ATM-CHK2 and ATR-CHK1 pathways for anticancer therapyTargeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.FOXM1 allows human keratinocytes to bypass the oncogene-induced differentiation checkpoint in response to gain of MYC or loss of p53.Phase I Study of LY2606368, a Checkpoint Kinase 1 Inhibitor, in Patients With Advanced CancerPotential biomarkers of DNA replication stress in cancer.Targeting lung cancer through inhibition of checkpoint kinases.Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice.Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding.A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells.Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis.The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability.Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription.Feedback regulation between atypical E2Fs and APC/CCdh1 coordinates cell cycle progression.Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart.A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR InhibitorsEfficacy of ATR inhibitors as single agents in Ewing sarcoma.A flow cytometry-based method to simplify the analysis and quantification of protein association to chromatin in mammalian cells.Evolutionary conservation of the CDK targets in eukaryotic DNA replication initiation.Molecular Pathways: Targeting ATR in Cancer TherapyThe EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors.Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism.BET bromodomain inhibitors synergize with ATR inhibitors in melanoma in melanomaDNA replication stress: from molecular mechanisms to human disease.BET bromodomain inhibitors synergize with ATR inhibitors to induce DNA damage, apoptosis, senescence-associated secretory pathway and ER stress in Myc-induced lymphoma cells.ATR inhibition rewires cellular signaling networks induced by replication stress.Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication.PTEN regulates DNA replication progression and stalled fork recovery.The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.The Role of the Transcriptional Response to DNA Replication Stress.The inactivation of rfaP, rarA or sspA gene improves the viability of the Escherichia coli DNA polymerase III holD mutant.Replication stress, DNA damage signalling, and cytomegalovirus infection in human medulloblastomas.TIPIN depletion leads to apoptosis in breast cancer cells.NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.Checkmate to CHK1 in T-cell ALL?TSC loss distorts DNA replication programme and sensitises cells to genotoxic stressStressed telomeres without POT1 enhance tumorigenesis
P2860
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P2860
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Replication stress and cancer: it takes two to tango.
@en
type
label
Replication stress and cancer: it takes two to tango.
@en
prefLabel
Replication stress and cancer: it takes two to tango.
@en
P2860
P1476
Replication stress and cancer: it takes two to tango
@en
P2093
Emilio Lecona
Oscar Fernández-Capetillo
P2860
P356
10.1016/J.YEXCR.2014.09.019
P407
P577
2014-09-26T00:00:00Z