Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions
about
Crystal structures of the structure-selective nuclease Mus81-Eme1 bound to flap DNA substratesThe Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondiiCooperativity of the SUMO and Ubiquitin Pathways in Genome StabilityHold your horSSEs: controlling structure-selective endonucleases MUS81 and Yen1/GEN1Nucleases in homologous recombination as targets for cancer therapyNucleo-cytoplasmic shuttling of the endonuclease ankyrin repeats and LEM domain-containing protein 1 (Ankle1) is mediated by canonical nuclear export- and nuclear import signalsHow SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest.A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous RecombinationThe Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates.Conditional genetic interactions of RTT107, SLX4, and HRQ1 reveal dynamic networks upon DNA damage in S. cerevisiae.Comprehensive classification of the PIN domain-like superfamilyCrossover recombination mediated by HIM-18/SLX4-associated nucleases.Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiaeBRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forksFanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repairDrosophila FANCM helicase prevents spontaneous mitotic crossovers generated by the MUS81 and SLX1 nucleases.Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.A physiological significance of the functional interaction between Mus81 and Rad27 in homologous recombination repairAtGEN1 and AtSEND1, two paralogs in Arabidopsis, possess holliday junction resolvase activity.Replication stress and cancer: it takes two to tango.Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex.Fanconi anemia proteins in telomere maintenance.Resolution of single and double Holliday junction recombination intermediates by GEN1.Holliday junction resolution: regulation in space and time.DNA damage repair machinery and HIV escape from innate immune sensing.Nuclease delivery: versatile functions of SLX4/FANCP in genome maintenance.Holliday junction resolvases.Resolution of Recombination Intermediates: Mechanisms and Regulation.Substrate specificity of the MUS81-EME2 structure selective endonuclease.Dual control of Yen1 nuclease activity and cellular localization by Cdk and Cdc14 prevents genome instability.G2/M cell cycle arrest correlates with primate lentiviral Vpr interaction with the SLX4 complex.Roles of SLX1-SLX4, MUS81-EME1, and GEN1 in avoiding genome instability and mitotic catastrophe.MUS81-EME2 promotes replication fork restart.Holliday junction-resolving enzymes-structures and mechanisms.DNA Replication Origins and Fork Progression at Mammalian TelomeresControl of Mus81 nuclease during the cell cycle.Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton RadiationStructural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease
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P2860
Human GEN1 and the SLX4-associated nucleases MUS81 and SLX1 are essential for the resolution of replication-induced Holliday junctions
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@ast
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@en
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@en-gb
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@nl
type
label
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@ast
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@en
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@en-gb
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@nl
prefLabel
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@ast
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@en
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@en-gb
Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@nl
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Human GEN1 and the SLX4-associ ...... ion-induced Holliday junctions
@en
P2093
Elizabeth Garner
Francis P Lach
Molly C Kottemann
Yonghwan Kim
P2860
P304
P3181
P356
10.1016/J.CELREP.2013.08.041
P407
P577
2013-10-17T00:00:00Z