Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
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Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunityThe Contribution of Chemokines and Migration to the Induction of Central Tolerance in the ThymusThymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance InductionStable interactions and sustained TCR signaling characterize thymocyte-thymocyte interactions that support negative selectionPremature expression of Foxp3 in double-negative thymocytesCCR4 promotes medullary entry and thymocyte-dendritic cell interactions required for central tolerance.Elimination of self-reactive T cells in the thymus: a timeline for negative selectionDeficiency of the metalloproteinase-disintegrin ADAM8 is associated with thymic hyper-cellularityPositive and negative selection of the T cell repertoire: what thymocytes see (and don't see)Distinct temporal patterns of T cell receptor signaling during positive versus negative selection in situDistinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns.A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway.Mechanisms of self-nonself discrimination and possible clinical relevance.Thymic nurse cells exhibit epithelial progenitor phenotype and create unique extra-cytoplasmic membrane space for thymocyte selectionCutting edge: Antigen-specific thymocyte feedback regulates homeostatic thymic conventional dendritic cell maturation.T cell-intrinsic and -extrinsic contributions of the IFNAR/STAT1-axis to thymocyte survival.Elevated T cell receptor signaling identifies a thymic precursor to the TCRαβ(+)CD4(-)CD8β(-) intraepithelial lymphocyte lineage.Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity.Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoire.Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia.ATM influences the efficiency of TCRβ rearrangement, subsequent TCRβ-dependent T cell development, and generation of the pre-selection TCRβ CDR3 repertoire.Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice.The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells.Dendritic cell control of tolerogenic responses.Prophylactic cancer vaccination by targeting functional non-selfGILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1.The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells.Autoimmune mediated regulation of ovarian tumor growth.Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8(+) T Lymphocytes.Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens.Requirement of Stat3 Signaling in the Postnatal Development of Thymic Medullary Epithelial Cells.Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity.Thymic gene transfer of myelin oligodendrocyte glycoprotein ameliorates the onset but not the progression of autoimmune demyelination.Selection of Thymocytes Expressing Transgenic TCR Specific for a Minor Histocompatibility Antigen, H60.Examination of thymic positive and negative selection by flow cytometry.Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.Murine thymic selection quantified using a unique method to capture deleted T cells.An Essential Role for the Transcription Factor Runx1 in T Cell Maturation
P2860
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P2860
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
@en
type
label
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
@en
prefLabel
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
@en
P2093
P2860
P356
P1476
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla
@en
P2093
Matthew S Wilken
Tom M McCaughtry
Troy A Baldwin
P2860
P304
P356
10.1084/JEM.20080866
P407
P577
2008-10-20T00:00:00Z