Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors.
about
The positive allosteric modulator morantel binds at noncanonical subunit interfaces of neuronal nicotinic acetylcholine receptorsDiscovery of potent positive allosteric modulators of the α3β2 nicotinic acetylcholine receptor by a chemical space walk in ChEMBL.Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiationSubunit interfaces contribute differently to activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Functional characterization of the 1,5-benzodiazepine clobazam and its major active metabolite N-desmethylclobazam at human GABA(A) receptors expressed in Xenopus laevis oocytes.Levamisole receptors: a second awakening.Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies.Glutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors.Intra-subunit flexibility underlies activation and allosteric modulation of neuronal nicotinic acetylcholine receptors.Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors.
P2860
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P2860
Morantel allosterically enhances channel gating of neuronal nicotinic acetylcholine alpha 3 beta 2 receptors.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Morantel allosterically enhanc ...... line alpha 3 beta 2 receptors.
@en
type
label
Morantel allosterically enhanc ...... line alpha 3 beta 2 receptors.
@en
prefLabel
Morantel allosterically enhanc ...... line alpha 3 beta 2 receptors.
@en
P2093
P2860
P356
P1476
Morantel allosterically enhanc ...... line alpha 3 beta 2 receptors.
@en
P2093
Caleb M Smith
Mark M Levandoski
Steven M Sine
P2860
P304
P356
10.1124/MOL.107.044388
P577
2008-05-05T00:00:00Z