G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
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Targeting the Mitotic Catastrophe Signaling Pathway in CancerGenotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cellsContext-Dependent Cell Cycle Checkpoint Abrogation by a Novel Kinase InhibitorStructure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold MorphingZds2p regulates Swe1p-dependent polarized cell growth in Saccharomyces cerevisiae via a novel Cdc55p interaction domain.Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agentsMolecular resistance fingerprint of pemetrexed and platinum in a long-term survivor of mesotheliomaWee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomasInduction of mitotic cell death by overriding G2/M checkpoint in endometrial cancer cells with non-functional p53.Mitotic catastrophe and cell death induced by depletion of centrosomal proteins.Centromere fragmentation is a common mitotic defect of S and G2 checkpoint override.Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2.Phase I, dose-escalation study of AZD7762 alone and in combination with gemcitabine in Japanese patients with advanced solid tumours.Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors.Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.The protein kinase Cdelta catalytic fragment is critical for maintenance of the G2/M DNA damage checkpointRole of senescence and mitotic catastrophe in cancer therapy.Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks.Chromatin-regulating proteins as targets for cancer therapy.DNA damage during G2 phase does not affect cell cycle progression of the green alga Scenedesmus quadricaudaMechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myelomaHistone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights.Probing the probes: fitness factors for small molecule tools.p38 mitogen-activated protein kinase promotes cell survival in response to DNA damage but is not required for the G(2) DNA damage checkpoint in human cancer cellsSuperaugmented eccentric distance sum connectivity indices: novel highly discriminating topological descriptors for QSAR/QSPR.Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.New insights into checkpoint kinase 1 in the DNA damage response signaling network.IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function.Xanthatin induces cell cycle arrest at G2/M checkpoint and apoptosis via disrupting NF-κB pathway in A549 non-small-cell lung cancer cells.Combined inhibition of Chk1 and Wee1: in vitro synergistic effect translates to tumor growth inhibition in vivo.Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.High expression of Wee1 is associated with poor disease-free survival in malignant melanoma: potential for targeted therapyLoss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway.ERK1/2 signaling plays an important role in topoisomerase II poison-induced G2/M checkpoint activation.Genomic homeostasis is dysregulated in favour of apoptosis in the colonic epithelium of the azoxymethane treated rat.RNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastomaA kinome screen identifies checkpoint kinase 1 (CHK1) as a sensitizer for RRM1-dependent gemcitabine efficacy.Carbon-ion beam irradiation kills X-ray-resistant p53-null cancer cells by inducing mitotic catastropheTranslating bioinformatics in oncology: guilt-by-profiling analysis and identification of KIF18B and CDCA3 as novel driver genes in carcinogenesis.
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G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 29 January 2008
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
@en
G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer.
@nl
type
label
G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
@en
G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer.
@nl
prefLabel
G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
@en
G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer.
@nl
P2860
P921
P356
P1476
G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.BJC.6604208
P407
P577
2008-01-29T00:00:00Z
2008-02-12T00:00:00Z