Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.
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Nucleases in homologous recombination as targets for cancer therapyUnpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleasesStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewTargeting DNA damage response in cancer therapyPredisposition to cancer caused by genetic and functional defects of mammalian Atad5Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active siteProteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic developmentPredicting human genetic interactions from cancer genome evolutionDroplet microfluidic technology for single-cell high-throughput screeningMechanisms of a novel anticancer therapeutic strategy involving atmospheric pressure plasma-mediated apoptosis and DNA strand break formation.Human synthetic lethal inference as potential anti-cancer target gene detectionSynthetic cytotoxicity: digenic interactions with TEL1/ATM mutations reveal sensitivity to low doses of camptothecinKinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3Synthetic lethality: general principles, utility and detection using genetic screens in human cellsSynthetic lethality of cohesins with PARPs and replication fork mediators.Inferring Genetic Interactions via a Data-Driven Second Order Model.Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity.Functional regulation of FEN1 nuclease and its link to cancerSynthetic lethality between gene defects affecting a single non-essential molecular pathway with reversible steps.Sister chromatid cohesion defects are associated with chromosome instability in Hodgkin lymphoma cells.Correlation of somatic mutation and expression identifies genes important in human glioblastoma progression and survival.Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination.The Overexpression of FEN1 and RAD54B May Act as Independent Prognostic Factors of Lung Adenocarcinoma.Lung cancer and DNA repair genes: multilevel association analysis from the International Lung Cancer ConsortiumMutability and mutational spectrum of chromosome transmission fidelity genesBase excision repair: contribution to tumorigenesis and target in anticancer treatment paradigmsHomologous recombination and its regulationGenomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells.Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork.Synthetic genetic targeting of genome instability in cancer.Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancerA comparative genomic approach for identifying synthetic lethal interactions in human cancer.Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells.A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilitiesTargeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression.Paclitaxel-resistant cancer cell-derived secretomes elicit ABCB1-associated docetaxel cross-resistance and escape from apoptosis through FOXO3a-driven glycolytic regulation.Uncovering synthetic lethal interactions for therapeutic targets and predictive markers in lung adenocarcinoma
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Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 13 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Specific synthetic lethal kill ...... ancer cells by FEN1 silencing.
@en
Specific synthetic lethal kill ...... ancer cells by FEN1 silencing.
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type
label
Specific synthetic lethal kill ...... ancer cells by FEN1 silencing.
@en
Specific synthetic lethal kill ...... ancer cells by FEN1 silencing.
@nl
prefLabel
Specific synthetic lethal kill ...... ancer cells by FEN1 silencing.
@en
Specific synthetic lethal kill ...... ancer cells by FEN1 silencing.
@nl
P2093
P2860
P356
P1476
Specific synthetic lethal kill ...... cancer cells by FEN1 silencing
@en
P2093
Irene J Barrett
Philip Hieter
Yasaman Nouhi
P2860
P304
P356
10.1073/PNAS.0813414106
P407
P577
2009-02-13T00:00:00Z