The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors.
about
Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomainEpimutational profile of hematologic malignancies as attractive target for new epigenetic therapiesThe multifaceted role of lysine acetylation in cancer: prognostic biomarker and therapeutic targetHistone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancyThe Role of Histone Acetyltransferases in Normal and Malignant HematopoiesisHBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic developmentExpression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos.An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets.Leukaemogenesis: more than mutant genesCrystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligands.Exchange of associated factors directs a switch in HBO1 acetyltransferase histone tail specificity.Bromodomain-PHD finger protein 1 is critical for leukemogenesis associated with MOZ-TIF2 fusion.Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain.The MOZ histone acetyltransferase in epigenetic signaling and disease.The chromatin regulator Brpf1 regulates embryo development and cell proliferationBivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation.KAT6A, a chromatin modifier from the 8p11-p12 amplicon is a candidate oncogene in luminal breast cancerDe novo nonsense mutations in KAT6A, a lysine acetyl-transferase gene, cause a syndrome including microcephaly and global developmental delayMOZ regulates B-cell progenitors and, consequently, Moz haploinsufficiency dramatically retards MYC-induced lymphoma development.Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatinT-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice.The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transitionBRPF1 is essential for development of fetal hematopoietic stem cellsMYST family histone acetyltransferases take center stage in stem cells and development.Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes.Epigenetic regulation of aging stem cells.Histone-modifying enzymes: their role in the pathogenesis of acute leukemia and their therapeutic potential.The MYSTerious MOZ, a histone acetyltransferase with a key role in haematopoiesis.Chromatin modifiers and the promise of epigenetic therapy in acute leukemiaKATapulting toward Pluripotency and Cancer.Expression of the MOZ-TIF2 oncoprotein in mice represses senescenceMOZ-mediated repression of p16(INK) (4) (a) is critical for the self-renewal of neural and hematopoietic stem cells.ING5 activity in self-renewal of glioblastoma stem cells via calcium and follicle stimulating hormone pathways.MOZ (MYST3, KAT6A) inhibits senescence via the INK4A-ARF pathway.Application of whole-exome sequencing to unravel the molecular basis of undiagnosed syndromic congenital neutropenia with intellectual disability.
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The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 05 March 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The histone acetyl transferase ...... n of hematopoietic precursors.
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The histone acetyl transferase ...... n of hematopoietic precursors.
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type
label
The histone acetyl transferase ...... n of hematopoietic precursors.
@en
The histone acetyl transferase ...... n of hematopoietic precursors.
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prefLabel
The histone acetyl transferase ...... n of hematopoietic precursors.
@en
The histone acetyl transferase ...... n of hematopoietic precursors.
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P1433
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The histone acetyl transferase ...... on of hematopoietic precursors
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P2093
Julian Borrow
Valerie Kouskoff
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P304
P356
10.1182/BLOOD-2008-04-152017
P407
P577
2009-03-05T00:00:00Z