OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3. - Test2 - elhamkhani - TriplyDB

OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.

OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.

http://www.wikidata.org/entity/Q37217722

about

Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling Fine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at work Expanding the ubiquitin code through post-translational modification Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1 FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1 Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase.Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling.The regulation of TGF-β/SMAD signaling by protein deubiquitination.OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer.OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.OTUB1 promotes tumor invasion and predicts a poor prognosis in gastric adenocarcinoma.Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer.Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein.Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis.The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways.DUBs, the regulation of cell identity and disease.Silencing of OTUB1 inhibits migration of human glioma cells in vitro.Ubiquitin Ligases and Deubiquitinating Enzymes in CD4+ T Cell Effector Fate Choice and Function.Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9.Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization.The role of deubiquitinases in breast cancer.Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield.An affinity-directed protein missile system for targeted proteolysis.WIDE AND THICK GRAIN 1, which encodes an otubain-like protease with deubiquitination activity, influences grain size and shape in rice.Characterization of Protein Complexes Using Chemical Cross-Linking Coupled Electrospray Mass Spectrometry.OTUB1 suppresses mTOR complex 1 (mTORC1) activity by deubiquitinating the mTORC1 inhibitor DEPTOR.Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation.The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.PAWS1 controls Wnt signalling through association with casein kinase 1α.Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor-3 Signaling Pathway Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction The role of K63-linked polyubiquitination in cardiac hypertrophy

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OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3.

http://www.wikidata.org/entity/Q37217722

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on January 2013

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

OTUB1 enhances TGFβ signalling ...... degradation of active SMAD2/3.

@en

OTUB1 enhances TGFβ signalling ...... degradation of active SMAD2/3.

@nl

type

label

OTUB1 enhances TGFβ signalling ...... degradation of active SMAD2/3.

@en

OTUB1 enhances TGFβ signalling ...... degradation of active SMAD2/3.

@nl

prefLabel

OTUB1 enhances TGFβ signalling ...... degradation of active SMAD2/3.

@en

OTUB1 enhances TGFβ signalling ...... degradation of active SMAD2/3.

@nl

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Nature Communications

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OTUB1 enhances TGFβ signalling ...... degradation of active SMAD2/3.

@en

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Gopal P Sapkota

http://www.w3.org/2001/XMLSchema#string

Lina Herhaus

http://www.w3.org/2001/XMLSchema#string

Simone Weidlich

http://www.w3.org/2001/XMLSchema#string

Thomas Macartney

http://www.w3.org/2001/XMLSchema#string

P2860

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1

Structural basis and specificity of human otubain 1-mediated deubiquitination

Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion

OTUB1 modulates c-IAP1 stability to regulate signalling pathways

The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines

Recognition of the polyubiquitin proteolytic signal

Otubains: a new family of cysteine proteases in the ubiquitin pathway

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2519

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scholarly article

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10.1038/NCOMMS3519

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4

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Mazin A Al-Salihi

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2013-01-01T00:00:00Z

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257135077

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1009866504

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24071738

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3791481

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