Population growth inflates the per-individual number of deleterious mutations and reduces their mean effect.
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Explosive genetic evidence for explosive human population growthThe population genomics of rhesus macaques (Macaca mulatta) based on whole-genome sequencesEvolutionary shaping of demographic schedules.Efficient inference of population size histories and locus-specific mutation rates from large-sample genomic variation data.A flexible method for estimating the fraction of fitness influencing mutations from large sequencing data sets.DESCARTES' RULE OF SIGNS AND THE IDENTIFIABILITY OF POPULATION DEMOGRAPHIC MODELS FROM GENOMIC VARIATION DATA.The impact of population demography and selection on the genetic architecture of complex traits.Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs.Refining the Y chromosome phylogeny with southern African sequences.Population genomics reveals seahorses (Hippocampus erectus) of the western mid-Atlantic coast to be residents rather than vagrantsNo evidence that selection has been less effective at removing deleterious mutations in Europeans than in AfricansDominance of Deleterious Alleles Controls the Response to a Population BottleneckThe effects of sample size on population genomic analyses--implications for the tests of neutrality.A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets.Explaining additional genetic variation in complex traitsSelection and explosive growth alter genetic architecture and hamper the detection of causal rare variants.Whole-exome sequencing in an isolated population from the Dalmatian island of VisEstimating the mutation load in human genomesNeutral genomic regions refine models of recent rapid human population growth.Distinguishing neutral from deleterious mutations in growing populations.Selective Landscapes in newt Immune Genes Inferred from Patterns of Nucleotide Variation.A Temporal Perspective on the Interplay of Demography and Selection on Deleterious Variation in Humans.The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives.When Is Selection Effective?Connecting within-host dynamics to the rate of viral molecular evolution.Characteristics of neutral and deleterious protein-coding variation among individuals and populations.The Impact of Linked Selection in Chimpanzees: A Comparative Study.
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Population growth inflates the per-individual number of deleterious mutations and reduces their mean effect.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 26 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Population growth inflates the ...... and reduces their mean effect.
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Population growth inflates the ...... and reduces their mean effect.
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Population growth inflates the ...... and reduces their mean effect.
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Population growth inflates the ...... and reduces their mean effect.
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Population growth inflates the ...... and reduces their mean effect.
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Population growth inflates the ...... and reduces their mean effect.
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Population growth inflates the ...... and reduces their mean effect.
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Alon Keinan
Andrew G Clark
Diana Chang
Elodie Gazave
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P304
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10.1534/GENETICS.113.153973
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P577
2013-08-26T00:00:00Z