SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication. - Test2 - elhamkhani - TriplyDB

SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

http://www.wikidata.org/entity/Q37336418

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New insights into an X-traordinary viral protein Restricting retrotransposons: a review Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP Quantitative Proteomic Approach Identifies Vpr Binding Protein as Novel Host Factor Supporting Influenza A Virus Infections in Human Cells.GTP activator and dNTP substrates of HIV-1 restriction factor SAMHD1 generate a long-lived activated state Mouse knockout models for HIV-1 restriction factors.dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.Intracellular immunity: finding the enemy within--how cells recognize and respond to intracellular pathogens Structural basis of cellular dNTP regulation by SAMHD1.Substrates and Inhibitors of SAMHD1.Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation.Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells.Understanding restriction factors and intrinsic immunity: insights and lessons from the primate lentiviruses.Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592 Phosphorylation of murine SAMHD1 regulates its antiretroviral activity Phosphorylation of mouse SAMHD1 regulates its restriction of human immunodeficiency virus type 1 infection, but not murine leukemia virus infection.Structural Insights into the High-efficiency Catalytic Mechanism of the Sterile α-Motif/Histidine-Aspartate Domain-containing Protein.Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1 Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1.Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.Interferon regulatory factor 3 is a key regulation factor for inducing the expression of SAMHD1 in antiviral innate immunity.Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.A Putative Cyclin-binding Motif in Human SAMHD1 Contributes to Protein Phosphorylation, Localization, and Stability.SAMHD1's protein expression profile in humans.Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.A molecular dynamics simulation study decodes the early stage of the disassembly process abolishing the human SAMHD1 function.Characterization of the interactions between SIVrcm Vpx and red-capped mangabey SAMHD1.Both plasmacytoid dendritic cells and monocytes stimulate natural killer cells early during human herpes simplex virus type 1 infections.Allosteric regulation of the human and mouse deoxyribonucleotide triphosphohydrolase sterile α-motif/histidine-aspartate domain-containing protein 1 (SAMHD1).DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV-1 infection of macrophages.Interferons: Reprogramming the Metabolic Network against Viral Infection.SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity.DNA damage induces a SAMHD1-mediated block to the infection of macrophages by HIV-1.Dephosphorylation of the HIV-1 restriction factor SAMHD1 is mediated by PP2A-B55α holoenzymes during mitotic exit.SAMHD1 Impairs HIV-1 Gene Expression and Negatively Modulates Reactivation of Viral Latency in CD4+ T-cells.Identification of Feline Interferon Regulatory Factor 1 as an Efficient Antiviral Factor against the Replication of Feline Calicivirus and Other Feline Viruses.The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

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SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

http://www.wikidata.org/entity/Q37336418

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 25 September 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

@en

SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

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type

label

SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

@en

SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

@nl

prefLabel

SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

@en

SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.

@nl

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Journal of Virology

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SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication

@en

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Eui Tae Kim

http://www.w3.org/2001/XMLSchema#string

Felipe Diaz-Griffero

http://www.w3.org/2001/XMLSchema#string

Matthew D Weitzman

http://www.w3.org/2001/XMLSchema#string

Tommy E White

http://www.w3.org/2001/XMLSchema#string

P2860

SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection

Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

The restriction factors of human immunodeficiency virus

How SAMHD1 changes our view of viral restriction

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

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12949-12956

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scholarly article

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10.1128/JVI.02291-13

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23

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87

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Alberto Brandariz-Nuñez

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2013-09-25T00:00:00Z

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24067963

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3838123

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