RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks. - Test2 - elhamkhani - TriplyDB

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

http://www.wikidata.org/entity/Q37421389

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Writers, Readers, and Erasers of Histone Ubiquitylation in DNA Double-Strand Break Repair Diagnostics of primary immunodeficiency diseases: a sequencing capture approach Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage RNF17 blocks promiscuous activity of PIWI proteins in mouse testes INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells.USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.Independent mechanisms recruit the cohesin loader protein NIPBL to sites of DNA damage.A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment Chronic oxidative stress promotes H2AX protein degradation and enhances chemosensitivity in breast cancer patients.H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.Recent advances in the study of immunodeficiency and DNA damage response.RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects.C9orf72 expansion disrupts ATM-mediated chromosomal break repair.Clinical and Biological Manifestation of RNF168 Deficiency in Two Polish Siblings.Acetylation of 53BP1 dictates the DNA double strand break repair pathway.An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168.Reading chromatin signatures after DNA double-strand breaks.53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM-CHK2-P53 pathway.Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response.Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability.Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks.Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

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RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

http://www.wikidata.org/entity/Q37421389

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 09 December 2013

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

@en

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

@nl

type

label

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

@en

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

@nl

prefLabel

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

@en

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

@nl

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PNAS.1320302111

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Proceedings of the National Academy of Sciences of the United States of America

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RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

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Anne Hakem

http://www.w3.org/2001/XMLSchema#string

Brian Raught

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Georges Maire

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Miyuki Bohgaki

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Razqallah Hakem

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Samah El Ghamrasni

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Stephanie Panier

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Tharan Srikumar

http://www.w3.org/2001/XMLSchema#string

Toshiyuki Bohgaki

http://www.w3.org/2001/XMLSchema#string

P2860

MDC1 is a mediator of the mammalian DNA damage checkpoint

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

UMI, a novel RNF168 ubiquitin binding domain involved in the DNA damage signaling pathway

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

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20982-20987

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scholarly article

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10.1073/PNAS.1320302111

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52

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Amélie Fradet-Turcotte

Grant S Stewart

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2013-12-09T00:00:00Z

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