about
Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombinationMDC1 is a mediator of the mammalian DNA damage checkpointThe RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damageBOD1L Is Required to Suppress Deleterious Resection of Stressed Replication ForksHuman Claspin works with BRCA1 to both positively and negatively regulate cell proliferationThe DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorderMutations in the NHEJ component XRCC4 cause primordial dwarfismIdentification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel SyndromeA role for E1B-AP5 in ATR signaling pathways during adenovirus infectionMediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression.Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndromeAdenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradationBET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemia.The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.ATM mutations in sporadic lymphoid tumours.A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour DevelopmentRIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signalingUbiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.Solving the RIDDLE of 53BP1 recruitment to sites of damage.PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.A PIAS-ed view of DNA double strand break repair focuses on SUMO.DNA double-strand break repair, immunodeficiency and the RIDDLE syndrome.A single strand that links multiple neuropathologies in human disease.A nervous predisposition to unrepaired DNA double strand breaks.Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus.USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status.Protection or resection: BOD1L as a novel replication fork protection factor.Activation of DNA Damage Response Pathways during Lytic Replication of KSHV.USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.The dual-acting chemotherapeutic agent Alchemix induces cell death independently of ATM and p53.Adenovirus E4orf3 targets transcriptional intermediary factor 1γ for proteasome-dependent degradation during infection.RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylationThe hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells.Serotype-specific inactivation of the cellular DNA damage response during adenovirus infection.53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair.Damaged replication forks tolerate USP7 to maintain genome stability
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description
researcher
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wetenschapper
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հետազոտող
@hy
name
Grant S Stewart
@en
Grant S Stewart
@es
Grant S Stewart
@nl
Grant S Stewart
@sl
type
label
Grant S Stewart
@en
Grant S Stewart
@es
Grant S Stewart
@nl
Grant S Stewart
@sl
prefLabel
Grant S Stewart
@en
Grant S Stewart
@es
Grant S Stewart
@nl
Grant S Stewart
@sl
P106
P21
P31
P496
0000-0002-0960-3241