Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy. - Test2 - elhamkhani - TriplyDB

Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy.

Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy.

http://www.wikidata.org/entity/Q37475156

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Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex.Dynamic Response of IFI16 and Promyelocytic Leukemia Nuclear Body Components to Herpes Simplex Virus 1 Infection New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16 The Role of Nuclear Antiviral Factors against Invading DNA Viruses: The Immediate Fate of Incoming Viral Genomes Innate immune recognition of DNA: A recent history International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses Dissecting How CD4 T Cells Are Lost During HIV Infection The nucleic acid-sensing inflammasomes IFI16 Preferentially Binds to DNA with Quadruplex Structure and Enhances DNA Quadruplex Formation Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1 Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.Assembly-driven activation of the AIM2 foreign-dsDNA sensor provides a polymerization template for downstream ASC Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract.Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence.Defining molecular signature of pro-immunogenic radiotherapy targets in human prostate cancer cells.cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection.IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP An updated view on the structure and function of PYRIN domains.Single-molecule imaging at high fluorophore concentrations by local activation of dye.Structural biology of innate immunity.Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity The emerging role of nuclear viral DNA sensors.NOD-like receptor signaling and inflammasome-related pathways are highlighted in psoriatic epidermis.Association of Antibodies to Interferon-Inducible Protein-16 With Markers of More Severe Disease in Primary Sjögren's Syndrome.Anti-Interferon-Inducible Protein 16 Antibodies Associate With Digital Gangrene in Patients With Scleroderma.Crystal structures of the bifunctional tRNA methyltransferase Trm5a Intracellular detection of viral nucleic acids.Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection.Cellular sensing of viral DNA and viral evasion mechanisms.The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation.The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines.Activation and regulation of DNA-driven immune responses.The cGAS-STING Defense Pathway and Its Counteraction by Viruses.Filament assemblies in foreign nucleic acid sensors.Viral evasion of DNA-stimulated innate immune responses.The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters.

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Cooperative assembly of IFI16 filaments on dsDNA provides insights into host defense strategy.

http://www.wikidata.org/entity/Q37475156

description

article científic

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article scientifique

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bilimsel makale

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scientific article published on 23 December 2013

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Cooperative assembly of IFI16 ...... ts into host defense strategy.

@en

Cooperative assembly of IFI16 ...... ts into host defense strategy.

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type

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Cooperative assembly of IFI16 ...... ts into host defense strategy.

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Cooperative assembly of IFI16 ...... ts into host defense strategy.

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prefLabel

Cooperative assembly of IFI16 ...... ts into host defense strategy.

@en

Cooperative assembly of IFI16 ...... ts into host defense strategy.

@nl

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Proceedings of the National Academy of Sciences of the United States of America

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Cooperative assembly of IFI16 ...... hts into host defense strategy

@en

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Jungsan Sohn

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Leeza M Constantoulakis

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Michael J Delannoy

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Seamus R Morrone

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Tao Wang

http://www.w3.org/2001/XMLSchema#string

P2860

IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes

IFI16 is an innate immune sensor for intracellular DNA

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion

Identification of specific autoantigens in Sjögren's syndrome by SEREX

Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: regulation of subcellular localization

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly

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