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CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombinationConnecting Malfunctioning Glial Cells and Brain Degenerative DisordersDNA End Resection: Facts and MechanismsCiliogenesis and the DNA damage response: a stressful relationshipThe role of cullin 5-containing ubiquitin ligasesNucleases in homologous recombination as targets for cancer therapyAtaxia-telangiectasia: future prospectsDNA damage and repair in atherosclerosis: current insights and future perspectivesMicrobial antigenic variation mediated by homologous DNA recombinationThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesDNA dynamics during early double-strand break processing revealed by non-intrusive imaging of living cellsATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complexMre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repairCrystal structure of the NurA-dAMP-Mn2+ complexDNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease ActivitiesStructure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signalingATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signalingEnd-resection at DNA double-strand breaks in the three domains of lifeEffect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitroDNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.Differential requirement for SUB1 in chromosomal and plasmid double-strand DNA break repairPARP inhibitors for BRCA1/2-mutated and sporadic ovarian cancer: current practice and future directionsUse of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinicMitochondrial DNA damage induced autophagy, cell death, and diseasePlasticity of the Leishmania genome leading to gene copy number variations and drug resistanceSystemic DNA damage responses in aging and diseasesEXD2 promotes homologous recombination by facilitating DNA end resectionStemness factor Sall4 is required for DNA damage response in embryonic stem cellsClinical significance of increased expression of Nijmegen breakage syndrome gene (NBS1) in human primary liver cancerMCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complexSite-specific DICER and DROSHA RNA products control the DNA-damage responseRelative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double-strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell linesDNA damage response genes and the development of cancer metastasisChemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cellsAn evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic developmentRECQL5 and BLM exhibit divergent functions in cells defective for the Fanconi anemia pathwayAn extended network of genomic maintenance in the archaeon Pyrococcus abyssi highlights unexpected associations between eucaryotic homologsFormation of linear amplicons with inverted duplications in Leishmania requires the MRE11 nucleaseTel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand BreaksTerminal differentiation of cardiac and skeletal myocytes induces permissivity to AAV transduction by relieving inhibition imposed by DNA damage response proteins
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description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2011
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The MRE11 complex: starting from the ends.
@en
The MRE11 complex: starting from the ends.
@nl
type
label
The MRE11 complex: starting from the ends.
@en
The MRE11 complex: starting from the ends.
@nl
prefLabel
The MRE11 complex: starting from the ends.
@en
The MRE11 complex: starting from the ends.
@nl
P2860
P356
P1476
The MRE11 complex: starting from the ends
@en
P2093
John H J Petrini
P2860
P2888
P304
P356
10.1038/NRM3047
P577
2011-02-01T00:00:00Z