Mammalian target of rapamycin signaling in cardiac physiology and disease.
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New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heartThe two faces of miR-29Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptationThe Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingmiR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activationInterplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease.Rab1 in cell signaling, cancer and other diseasesAn activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E⁻/⁻ mice.STAT3 balances myocyte hypertrophy vis-à-vis autophagy in response to Angiotensin II by modulating the AMPKα/mTOR axis.Alive and well? Exploring disease by studying lifespan.A time to reap, a time to sow: mitophagy and biogenesis in cardiac pathophysiologyHexokinase II integrates energy metabolism and cellular protection: Akting on mitochondria and TORCing to autophagy.AMP-activated protein kinase deficiency rescues paraquat-induced cardiac contractile dysfunction through an autophagy-dependent mechanismbFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway.This old heart: Cardiac aging and autophagy.Cardiac mTOR rescues the detrimental effects of diet-induced obesity in the heart after ischemia-reperfusion.Ivabradine Prevents Low Shear Stress Induced Endothelial Inflammation and Oxidative Stress via mTOR/eNOS Pathway.The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunctionMutations of RagA GTPase in mTORC1 Pathway Are Associated with Autosomal Dominant Cataracts.A H(a)rd Way to Adapt in Cardiac Hypertrophy.Loss of long-chain acyl-CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation.The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload.Regulation of cardiac miR-208a, an inducer of obesity, by rapamycin and nebivolol.Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning.Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal InjuryActivation of the Mammalian Target of Rapamycin in the Rostral Ventromedial Medulla Contributes to the Maintenance of Nerve Injury-Induced Neuropathic Pain in RatInterleukin-10 inhibits chronic angiotensin II-induced pathological autophagyN-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy.Drp1-Dependent Mitochondrial Autophagy Plays a Protective Role Against Pressure Overload-Induced Mitochondrial Dysfunction and Heart Failure.Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling.Calpain 2-mediated autophagy defect increases susceptibility of fatty livers to ischemia-reperfusion injury.Aging and Autophagy in the HeartPharmacological Strategies to Retard Cardiovascular AgingNutrient-sensing mTORC1: Integration of metabolic and autophagic signalsAsiatic Acid Protects against Cardiac Hypertrophy through Activating AMPKα Signalling Pathway.CITED4 induces physiologic hypertrophy and promotes functional recovery after ischemic injury.Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling.Identify potential drugs for cardiovascular diseases caused by stress-induced genes in vascular smooth muscle cells.Metabolomics reveals the mechanisms for the cardiotoxicity of Pinelliae Rhizoma and the toxicity-reducing effect of processingNerve growth factor-induced Akt/mTOR activation protects the ischemic heart via restoring autophagic flux and attenuating ubiquitinated protein accumulation.
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Mammalian target of rapamycin signaling in cardiac physiology and disease.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2014
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Mammalian target of rapamycin signaling in cardiac physiology and disease.
@en
Mammalian target of rapamycin signaling in cardiac physiology and disease.
@nl
type
label
Mammalian target of rapamycin signaling in cardiac physiology and disease.
@en
Mammalian target of rapamycin signaling in cardiac physiology and disease.
@nl
prefLabel
Mammalian target of rapamycin signaling in cardiac physiology and disease.
@en
Mammalian target of rapamycin signaling in cardiac physiology and disease.
@nl
P2860
P50
P1433
P1476
Mammalian target of rapamycin signaling in cardiac physiology and disease
@en
P2093
Junichi Sadoshima
Sebastiano Sciarretta
P2860
P304
P356
10.1161/CIRCRESAHA.114.302022
P577
2014-01-01T00:00:00Z