ATM protein kinase: the linchpin of cellular defenses to stress.
about
Genetics and genomics of radiotherapy toxicity: towards predictionOxidative stress, bone marrow failure, and genome instability in hematopoietic stem cellsCellular stress response and innate immune signaling: integrating pathways in host defense and inflammation.Systemic DNA damage responses in aging and diseasesATM, ATR and DNA-PKcs expressions correlate to adverse clinical outcomes in epithelial ovarian cancersRedox homeostasis: the linchpin in stem cell self-renewal and differentiationATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescenceNitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenanceEssential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2.Spatiotemporal dynamics of early DNA damage response proteins on complex DNA lesions.A New Player in the Development of TRAIL Based Therapies for Hepatocarcinoma Treatment: ATM Kinase.Tug of war between survival and death: exploring ATM function in cancer.ATM prevents DSB formation by coordinating SSB repair and cell cycle progression.Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks.ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila.The autotaxin-LPA2 GPCR axis is modulated by γ-irradiation and facilitates DNA damage repair.Kinase-dead ATM protein causes genomic instability and early embryonic lethality in miceProteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity.The cellular ataxia telangiectasia-mutated kinase promotes epstein-barr virus lytic reactivation in response to multiple different types of lytic reactivation-inducing stimuliAtaxia telangiectasia mutated impacts insulin-like growth factor 1 signalling in skeletal muscle.The ATM signaling network in development and disease.Reactive Oxygen Species (ROS)-Activated ATM-Dependent Phosphorylation of Cytoplasmic Substrates Identified by Large-Scale Phosphoproteomics ScreenThe innate immune response transcription factor relish is necessary for neurodegeneration in a Drosophila model of ataxia-telangiectasia.Recent progress in mouse models for tumor suppressor genes and its implications in human cancer.Tumor protein D52 represents a negative regulator of ATM protein levels.Impaired insulin-stimulated glucose transport in ATM-deficient mouse skeletal muscle.Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.ATM kinase activity modulates ITCH E3-ubiquitin ligase activity.Upon the tightrope in prostate cancer: two acrobats on the same tightrope to cross the finishline.Implications of multipotent mesenchymal stromal cell aging.Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.Ran Binding Protein 9 (RanBP9) is a novel mediator of cellular DNA damage response in lung cancer cells.Oxidative stress shapes breast cancer phenotype through chronic activation of ATM-dependent signaling.Effects of tumor-suppressor lysyl oxidase propeptide on prostate cancer xenograft growth and its direct interactions with DNA repair pathways.Ataxia-telangiectasia mutated kinase-mediated upregulation of NKG2D ligands on leukemia cells by resveratrol results in enhanced natural killer cell susceptibility.Mechanisms of DNA damage, repair, and mutagenesis.ATM is required for SOD2 expression and homeostasis within the mammary gland.Ataxia-Telangiectasia Mutated (ATM) Protein Signaling Participates in Development of Pulmonary Arterial Hypertension in Rats.
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ATM protein kinase: the linchpin of cellular defenses to stress.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 02 May 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
ATM protein kinase: the linchpin of cellular defenses to stress.
@en
ATM protein kinase: the linchpin of cellular defenses to stress.
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ATM protein kinase: the linchpin of cellular defenses to stress.
@en
ATM protein kinase: the linchpin of cellular defenses to stress.
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prefLabel
ATM protein kinase: the linchpin of cellular defenses to stress.
@en
ATM protein kinase: the linchpin of cellular defenses to stress.
@nl
P2093
P2860
P1476
ATM protein kinase: the linchpin of cellular defenses to stress.
@en
P2093
Ammad Ahmad Farooqi
Kum Kum Khanna
Martin Lavin
Sergei Kozlov
Shahzad Bhatti
P2860
P2888
P304
P356
10.1007/S00018-011-0683-9
P577
2011-05-02T00:00:00Z