Mechanisms of human histone and nucleic acid demethylases.
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Metabolic methanol: molecular pathways and physiological rolesMechanism and function of oxidative reversal of DNA and RNA methylationHuman UTY(KDM6C) Is a Male-specific N -Methyl Lysyl DemethylaseRibosomal oxygenases are structurally conserved from prokaryotes to humansStructural analysis of human KDM5B guides histone demethylase inhibitor developmentUndercover: gene control by metabolites and metabolic enzymesDevelopment of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells.Targeting histone lysine demethylases - progress, challenges, and the futureProtein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases.Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen.Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylasesProteasome activity is important for replication recovery, CHK1 phosphorylation and prevention of G2 arrest after low-dose formaldehyde.Studies on the Glutathione-Dependent Formaldehyde-Activating Enzyme from Paracoccus denitrificansOptimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitorDocking and Linking of Fragments To Discover Jumonji Histone Demethylase Inhibitors.Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch.ATM and KAT5 safeguard replicating chromatin against formaldehyde damage.Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolismNucleic acid oxidation in DNA damage repair and epigeneticsSensing cellular states--signaling to chromatin pathways targeting Polycomb and Trithorax group function.A new role for LOX and LOXL2 proteins in transcription regulation.Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.LSD1 inhibitors: a patent review (2010-2015).Structural aspects of small-molecule inhibition of methyllysine reader proteins.Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation.Alcohol Dehydrogenase 5 Is a Source of Formate for De Novo Purine Biosynthesis in HepG2 Cells.An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.Fluorescent probes for imaging formaldehyde in biological systems.5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates.Modulating carnitine levels by targeting its biosynthesis pathway - selective inhibition of γ-butyrobetaine hydroxylase.Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.Is JmjC oxygenase catalysis limited to demethylation?Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells.The Antioxidant Cofactor Alpha-Lipoic Acid May Control Endogenous Formaldehyde Metabolism in Mammals.Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.Formation and repair of DNA-protein crosslink damage.Neurotoxicity effect of formaldehyde on occupational exposure and influence of individual susceptibility to some metabolism parameters.Origin of low-molecular mass aldehydes as disinfection by-products in beverages.Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation.
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P2860
Mechanisms of human histone and nucleic acid demethylases.
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article científic
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article scientifique
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articol științific
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articolo scientifico
@it
artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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name
Mechanisms of human histone and nucleic acid demethylases.
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type
label
Mechanisms of human histone and nucleic acid demethylases.
@en
prefLabel
Mechanisms of human histone and nucleic acid demethylases.
@en
P50
P1476
Mechanisms of human histone and nucleic acid demethylases.
@en
P304
P356
10.1016/J.CBPA.2012.09.015
P577
2012-10-10T00:00:00Z