Dysregulation of the basal RNA polymerase transcription apparatus in cancer.
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The basal transcription machinery as a target for cancer therapyNucleolar responses to DNA double-strand breaksMYC, Metabolism, and CancerTargeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human diseaseInhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signalingPTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challengesSpt6 Is Essential for rRNA Synthesis by RNA Polymerase I.Omics Pipe: a community-based framework for reproducible multi-omics data analysis.Mechanisms of genome instability induced by RNA-processing defects.The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomasThe pre-rRNA processing factor DEF is rate limiting for the pathogenesis of MYCN-driven neuroblastoma.A mathematical theory of the transcription repression (TR) therapy of cancer - whether and how it may work.The role of nuclear bodies in gene expression and disease.Conditional inactivation of Upstream Binding Factor reveals its epigenetic functions and the existence of a somatic nucleolar precursor bodyA novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes.Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress.Ribonucleic acid (RNA) biosynthesis in human cancer.Altered expression pattern of circular RNAs in primary and metastatic sites of epithelial ovarian carcinoma.A cyclin-dependent kinase inhibitor, dinaciclib in preclinical treatment models of thyroid cancer.Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell ProliferationTransient-State Kinetic Analysis of the RNA Polymerase I Nucleotide Incorporation Mechanism.Therapeutic interventions to disrupt the protein synthetic machinery in melanomaMicroRNA degeneracy and pluripotentiality within a Lavallière-tie architecture confers robustness to gene expression networks.Etoposide induced cytotoxicity mediated by ROS and ERK in human kidney proximal tubule cells.Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcriptionThe Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer.Targeting RNA polymerase I to treat MYC-driven cancer.Regulation of ribosomal gene expression in cancer.mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels.Protein and nucleotide biosynthesis are coupled by a single rate-limiting enzyme, PRPS2, to drive cancer.Design, synthesis, and structure-activity relationships of pyridoquinazolinecarboxamides as RNA polymerase I inhibitors.Influence of node abundance on signaling network state and dynamics analyzed by mass cytometry.A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.Gene expression profile of the whole Mediator complex in human osteosarcoma and normal osteoblasts.Transcriptional Addiction in Cancer.Transformation-induced changes in the DNA-nuclear matrix interface, revealed by high-throughput analysis of DNA halosIncreased global transcription activity as a mechanism of replication stress in cancerThe identification of a novel role for BRCA1 in regulating RNA polymerase I transcription.Determining the Molecular Pathways Underlying the Protective Effect of Non-Steroidal Anti-Inflammatory Drugs for Alzheimer's Disease: A Bioinformatics Approach.
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Dysregulation of the basal RNA polymerase transcription apparatus in cancer.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Dysregulation of the basal RNA polymerase transcription apparatus in cancer.
@en
type
label
Dysregulation of the basal RNA polymerase transcription apparatus in cancer.
@en
prefLabel
Dysregulation of the basal RNA polymerase transcription apparatus in cancer.
@en
P50
P356
P1476
Dysregulation of the basal RNA polymerase transcription apparatus in cancer.
@en
P2093
Megan J Bywater
P2888
P304
P356
10.1038/NRC3496
P407
P577
2013-05-01T00:00:00Z
P5875
P6179
1021421962