Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. - Test2 - elhamkhani - TriplyDB

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

http://www.wikidata.org/entity/Q34388531

about

The transcriptional cofactor TRIM33 prevents apoptosis in B lymphoblastic leukemia by deactivating a single enhancer MYC, Metabolism, and Cancer Pancreatic Cancer, A Mis-interpreter of the Epigenetic Language The mechanisms behind the therapeutic activity of BET bromodomain inhibition IDH-mutant glioma specific association of rs55705857 located at 8q24.21 involves MYC deregulation Brd4 inhibition attenuates unilateral ureteral obstruction-induced fibrosis by blocking TGF-β-mediated Nox4 expression Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition The SWI/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition.A SWI/SNF Chromatin Remodelling Protein Controls Cytokinin Production through the Regulation of Chromatin Architecture.Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling Systematic mapping of functional enhancer-promoter connections with CRISPR interference.Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth.MYC Deregulation in Primary Human Cancers.A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia.Looping back to leap forward: transcription enters a new era Targeting transcription regulation in cancer with a covalent CDK7 inhibitor Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.Uncovering enhancer functions using the α-globin locus.Brg1 modulates enhancer activation in mesoderm lineage commitment.Disease networks. Uncovering disease-disease relationships through the incomplete interactome Mesenchymal stromal cells derived from acute myeloid leukemia bone marrow exhibit aberrant cytogenetics and cytokine elaboration.The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth.BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.Chromatin Remodelers: From Function to Dysfunction.SWI/SNF Subunits SMARCA4, SMARCD2 and DPF2 Collaborate in MLL-Rearranged Leukaemia Maintenance Signal transducer and activator of transcription STAT5 is recruited to c-Myc super-enhancer.Amplification of the bromodomain-containing protein 4 gene in ovarian high-grade serous carcinoma is associated with worse prognosis and survival NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler.The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies.Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex BET Bromodomain Inhibition Releases the Mediator Complex from Select cis-Regulatory Elements.Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case.BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies.Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.

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Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

http://www.wikidata.org/entity/Q34388531

description

2013 nî lūn-bûn

@nan

2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

@ast

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

@en

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

@nl

type

label

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

@ast

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

@en

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

@nl

prefLabel

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

@ast

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

@en

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

@nl

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Genes & Development

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Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.

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Chen Shen

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Christian Haslinger

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Cinthya J Zepeda-Mendoza

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David L Spector

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Eric Wang

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Fatih Mercan

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Gerd A Blobel

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Jae-Seok Roe

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Jessica L Minder

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Joseph P Milazzo

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The spectrum of SWI/SNF mutations, ubiquitous in human cancers

Selective inhibition of BET bromodomains

Identification of a polymorphic, neuron-specific chromatin remodeling complex

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex

BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

Solution structure of human Brg1 bromodomain and its specific binding to acetylated histone tails

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex

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2648-2662

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10.1101/GAD.232710.113

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24

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27

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Mélanie A Eckersley-Maslin

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2013-11-27T00:00:00Z

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258958085

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24285714

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3877755

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