Insulin-degrading enzyme is exported via an unconventional protein secretion pathway. - Test2 - elhamkhani - TriplyDB

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway.

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway.

http://www.wikidata.org/entity/Q38474373

about

Potential Role of Epigenetic Mechanism in Manganese Induced Neurotoxicity Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion Macroautophagy and cell responses related to mitochondrial dysfunction, lipid metabolism and unconventional secretion of proteins Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening Unraveling Alzheimer's: Making Sense of the Relationship between Diabetes and Alzheimer's Disease1 Mechanisms of enzymatic degradation of amyloid Beta microfibrils generating nanofilaments and nanospheres related to cytotoxicity.Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation.Dynamic regulatory network reconstruction for Alzheimer's disease based on matrix decomposition techniques.Analysis of mouse brain peptides using mass spectrometry-based peptidomics: implications for novel functions ranging from non-classical neuropeptides to microproteins.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Analyzing microarray data of Alzheimer's using cluster analysis to identify the biomarker genes.Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease Proteasome Activity Is Affected by Fluctuations in Insulin-Degrading Enzyme Distribution.Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.A novel, sensitive assay for behavioral defects in Parkinson's disease model Drosophila Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway.Identification of BACE2 as an avid ß-amyloid-degrading protease Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease?Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}Development of monoclonal antibodies and quantitative ELISAs targeting insulin-degrading enzyme.Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer's disease?Proteolytic degradation of amyloid β-protein.The Role of p38 MAPK and Its Substrates in Neuronal Plasticity and Neurodegenerative Disease.Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.BRI2 protein regulates β-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).New Insights into Epigenetic and Pharmacological Regulation of Amyloid-Degrading Enzymes.Common Pesticide, Dichlorodiphenyltrichloroethane (DDT), Increases Amyloid-β Levels by Impairing the Function of ABCA1 and IDE: Implication for Alzheimer's Disease.Insulin-degrading enzyme (IDE): a novel heat shock-like protein.Phosphorylation of amyloid-β peptide at serine 8 attenuates its clearance via insulin-degrading and angiotensin-converting enzymes.Autophagy: a broad role in unconventional protein secretion?Functional relevance of a novel SlyX motif in non-conventional secretion of insulin-degrading enzyme.Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes.Connexin-Based Therapeutics and Tissue Engineering Approaches to the Amelioration of Chronic Pancreatitis and Type I Diabetes: Construction and Characterization of a Novel Prevascularized Bioartificial Pancreas.Insulin-degrading enzyme is not secreted from cultured cells.Multiple functions of insulin-degrading enzyme: a metabolic crosslight?Copper(I) and copper(II) inhibit Aβ peptides proteolysis by insulin-degrading enzyme differently: implications for metallostasis alteration in Alzheimer's disease.Unconventional Secretion and Intercellular Transfer of Mutant Huntingtin.Insulin transport into the brain

P2860

Q26744563-F308DEC0-90E0-42B8-8BE2-1DC3E6EADEEF Q27661904-9E12B588-6C43-4D2F-96D5-64576C90CE33 Q28294279-61760B5A-485A-4A8A-B203-C96BCE07FE3D Q28394794-9A6BB088-F232-445F-879B-EBF579622FE8 Q28475342-D8645E03-AEDE-4076-8F72-46A3DFD757A4 Q33362745-3B153E34-F510-4B57-812F-8C80803B66FB Q33536103-E1967CC6-D250-484F-ADBA-097AE271204F Q33689637-78C749D6-98B5-42B7-B7CF-9D0E588436B0 Q33849792-049DC3E9-F59C-4C70-AAF1-1375F5055D36 Q33987281-8FB9FC95-12D2-4FF4-9046-CD733833E26F Q34110227-178F8F43-56D4-46DD-B4CC-545FC09E38B8 Q34223702-B3646C0E-573F-4372-879E-056CBEDC05BD Q35552504-68B6A2AD-7985-474E-B2DD-F198E53DEB17 Q35694579-F418AE43-917C-4ABA-BA3D-8C0EE7D83C82 Q35953055-B748D871-8C27-449C-BFF1-D4236F567C8D Q36135025-D73A2970-B0DF-4250-ADC8-0BCEAE8C6342 Q36235102-1DCAD48A-FF40-4C95-BC13-1C16F546B49D Q36316174-D2E4311F-84A8-46D7-AF61-83AA09CCC91B Q37045391-B45E6705-DE94-412C-8650-7F9FDBD7F5D8 Q37200279-F81230C6-FB08-4BCF-84E4-D84E2EE7840E Q37253971-569F970A-8158-442C-9EA2-C6652236243B Q37402080-94402BC7-FC0B-4524-B24B-AFB0CD466B7B Q37961852-B7B82A5A-D0DC-4DA4-9998-D724EA196409 Q38016899-57FA4963-821E-426F-A8FC-9AF01E341077 Q38026044-4B053DA0-B009-46BA-8FFC-BA5D585F664C Q38256360-26DECC94-91BF-49C7-AC43-10DD5637F1F6 Q38795575-18A00E4D-C913-47FA-9F8B-4BCFCAF60154 Q38834930-79209E7F-D506-4E1D-8AF7-0F6BD764F517 Q38905832-8AAF6217-8380-4FA4-B6F2-85A573640360 Q39236799-99E055FC-D46F-4D8A-8636-B3B6ED9A641D Q39407972-CF8D87C5-4900-44B4-A798-EBB99B9E7E63 Q41768305-1248AC90-5884-48E6-9CA3-ED521E7E5039 Q41788885-F3589356-52C3-49B7-A4CB-1BAB772F7618 Q41826610-17AD47C6-9832-4DED-94E5-361D99EADE5C Q42120003-7A254E3F-49EC-4648-85A2-0E66EFE893E5 Q49199697-C079A38E-2313-4386-AA87-8D3F866E12A2 Q50932512-E63A9823-1338-4C9B-AA9A-6EAB9A7E9339 Q51608953-319E447B-C934-4114-9EF2-94FCAF8127E1 Q55515366-FA9BF05F-0E66-4BCC-8F9B-1E3C6555E003 Q56334573-57779C85-CF69-4029-96C7-62B6B4C1F515

P2860

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway.

http://www.wikidata.org/entity/Q38474373

description

2009 nî lūn-bûn

@nan

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

2009年论文

@zh

2009年论文

@zh-cn

name

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway.

@en

type

label

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway.

@en

prefLabel

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway.

@en

P1433

Q38474373-683BFE5C-C1A8-4E30-9B61-B183FC451EA5

P1476

Q38474373-0DDD9CE5-3F50-412C-A90B-BECFC8E80A4E

P2093

Q38474373-353B1577-E4A4-4BA7-9284-2171248ED43F

Q38474373-3AAFD789-EDF6-47F8-B657-9CAA6234A777

Q38474373-9B8B91C5-4477-404F-BD5A-C1815FC598D5

P2860

Q38474373-0939D937-502D-4C3E-9565-343D760BFD7E

Q38474373-0F8CDC69-0160-4D91-BFD2-F71BC5D6F62F

Q38474373-2DA2E71A-9A08-441C-9179-F82938C32F9F

Q38474373-48A5E962-C92D-490E-8F90-F2393C30E187

Q38474373-50D4EC40-6AA3-40AF-B87A-F33B7C4C9FC7

Q38474373-5D985774-DF31-4C65-91FA-89A05813839E

Q38474373-7CA01ED3-E1CF-468F-A3BB-5F3DE85E4726

Q38474373-886FB74F-B2B8-4339-9AB2-B0CFAFA2D9B6

Q38474373-93F4D311-63A6-48D8-8055-02A0D753F5D4

Q38474373-97BE65A0-80CF-4D21-83A6-66F5BB40F1EE

P2888

Q38474373-EA280E2B-E417-4BE2-B0C1-AE570BC86292

P304

Q38474373-76E29C9B-5145-43D7-B52C-9BA737901197

P31

Q38474373-E4559D7D-B434-48B5-BAEE-E39574EC0983

P356

Q38474373-37FD4A47-05C1-495E-9F23-A069F29242FD

P478

Q38474373-E09B7038-F0D0-4853-BF10-E0DA60CCFAFE

P577

Q38474373-2245F0BA-2450-4745-AC2A-1C11BEFE95AA

P5875

Q38474373-AAF36449-5B5E-437E-B538-2A74525F99BC

P6179

Q38474373-9EB01C07-C46A-4997-9414-2C2F812C5B6F

P698

Q38474373-717DA804-922E-4A2C-8279-1528DA280E6B

P921

Q38474373-7C490E87-C21A-458C-89DE-D2D4AB69F9C4

P932

Q38474373-37641E38-6EED-47AE-A8E3-7567001B5C22

P356

P1433

Molecular Neurodegeneration

P1476

Insulin-degrading enzyme is exported via an unconventional protein secretion pathway.

@en

P2093

Ji Zhao

http://www.w3.org/2001/XMLSchema#string

Lilin Li

http://www.w3.org/2001/XMLSchema#string

Malcolm A Leissring

http://www.w3.org/2001/XMLSchema#string

P2860

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism

Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE

The insulysin (insulin degrading enzyme) enigma

Insulin degradation: progress and potential

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

Exosomes: endosomal-derived vesicles shipping extracellular messages.

An unusual active site identified in a family of zinc metalloendopeptidases

Alpha 1-antitrypsin: structure, function and molecular biology of the gene.

P2888

P304

4

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1186/1750-1326-4-4

http://www.w3.org/2001/XMLSchema#string

P478

4

http://www.w3.org/2001/XMLSchema#string

P577

2009-01-14T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

23788280

http://www.w3.org/2001/XMLSchema#string

P6179

1035758720

http://www.w3.org/2001/XMLSchema#string

P698

19144176

http://www.w3.org/2001/XMLSchema#string

P921

P932

2632642

http://www.w3.org/2001/XMLSchema#string