Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia. - Test2 - elhamkhani - TriplyDB

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.

http://www.wikidata.org/entity/Q36159459

about

Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension The CUL3/KLHL3-WNK-SPAK/OSR1 pathway as a target for antihypertensive therapy Hypertension: the missing WNKs.Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism.WNK signalling pathways in blood pressure regulation PPARγ Regulation in Hypertension and Metabolic Syndrome.ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation.Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.Ubiquitination and the Regulation of Membrane Proteins.Genetic screening in arterial hypertension.Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3.A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions.Mutant Cullin causes cardiovascular compromise.Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects.Potassium-Regulated Distal Tubule WNK Bodies are Kidney-Specific WNK1 Dependent.The evolving field of salt transport regulation in the Steve Hebert Lecture.Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion.Mechanisms and controversies in mutant Cul3-mediated Familial Hyperkalemic Hypertension.New Insights into the Role of E2s in the Pathogenesis of Diseases: Lessons Learned from UBE2O.

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P2860

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.

http://www.wikidata.org/entity/Q36159459

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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2015年论文

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Characterisation of the Cullin ...... ypertension and hyperkalaemia.

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Characterisation of the Cullin ...... ypertension and hyperkalaemia.

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Characterisation of the Cullin ...... ypertension and hyperkalaemia.

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Characterisation of the Cullin ...... ypertension and hyperkalaemia.

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Characterisation of the Cullin ...... ypertension and hyperkalaemia.

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Characterisation of the Cullin ...... ypertension and hyperkalaemia.

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EMBO Molecular Medicine

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Characterisation of the Cullin ...... ypertension and hyperkalaemia.

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Axel Knebel

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Clare Johnson

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Frances-Rose Schumacher

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James T Ferryman

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Jinwei Zhang

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Kevin M O'Shaughnessy

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Nichola L Figg

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Radoslav Enchev

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Raya S Al Maskari

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Sarah E Cleary

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P2860

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8

A ubiquitin ligase complex assembles linear polyubiquitin chains

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells

Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

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10.15252/EMMM.201505444

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