Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
about
The broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillanceThe Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint SignalingLB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potentialKinetochore-microtubule attachment is sufficient to satisfy the human spindle assembly checkpointThe human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochoresA Centromere-Signaling Network Underlies the Coordination among Mitotic EventsConnecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint.Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylationInner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing.BOD1 Is Required for Cognitive Function in Humans and Drosophila.Dynamic localization of Mps1 kinase to kinetochores is essential for accurate spindle microtubule attachmentControl of APC/C-dependent ubiquitin chain elongation by reversible phosphorylationAcetylation of Aurora B by TIP60 ensures accurate chromosomal segregationMitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localizationThe Phosphatase Dusp7 Drives Meiotic Resumption and Chromosome Alignment in Mouse OocytesStag3 regulates microtubule stability to maintain euploidy during mouse oocyte meiotic maturation.Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progressionHow oocytes try to get it right: spindle checkpoint control in meiosis.Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch.Molecular basis underlying resistance to Mps1/TTK inhibitors.Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation.Melatonin protects oocyte quality from Bisphenol A-induced deterioration in the mouse.Regulation of Cell Division.Playing polo during mitosis: PLK1 takes the lead.Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore.Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells.A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint.Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model.Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation.Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing.Mitotic kinases and phosphatases cooperate to shape the right response.Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension.Molecular Mechanisms of Spindle Assembly Checkpoint Activation and Silencing.Phosphatase-regulated recruitment of the spindle- and kinetochore-associated (Ska) complex to kinetochores.The Ndc80 complex targets Bod1 to human mitotic kinetochores.The Ins and Outs of Aurora B Inner Centromere Localization.PP2A as the Main Node of Therapeutic Strategies and Resistance Reversal in Triple-Negative Breast Cancer.
P2860
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P2860
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh
2014年學術文章
@zh-hant
name
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
@en
type
label
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
@en
prefLabel
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
@en
P50
P356
P1433
P1476
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal
@en
P2093
Antoinette Teixeira
Wilco Nijenhuis
P2888
P304
P356
10.1038/NCB3065
P577
2014-11-17T00:00:00Z
P6179
1044241375