Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
about
Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid.Optimization of the antiviral potency and lipophilicity of halogenated 2,6-diarylpyridinamines as a novel class of HIV-1 NNRTIS.Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors.Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors.A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases.A 2D-QSAR and Grid-Independent Molecular Descriptor (GRIND) Analysis of Quinoline-Type Inhibitors of Akt2: Exploration of the Binding Mode in the Pleckstrin Homology (PH) DomainOn the origin of large flexibility of P-glycoprotein in the inward-facing stateStructure-activity relationships and in silico models of P-glycoprotein (ABCB1) inhibitors.Negative inotropism of terpenes on guinea pig left atrium: structure-activity relationships.Scaffold identification of a new class of potent and selective BCRP inhibitors.Large-scale classification of P-glycoprotein inhibitors using SMILES-based descriptors.2D- and 3D-QSAR studies of a series of benzopyranes and benzopyrano[3,4b][1,4]-oxazines as inhibitors of the multidrug transporter P-glycoprotein.Soybean Milk Inhibits Absorption and Intestinal Transmembrane Transport of Gegen in Rats.Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein.Efficient Synthesis of Diaryl Ketones by Nickel-Catalyzed Negishi Cross-Coupling of Amides by Carbon-Nitrogen Bond Cleavage at Room Temperature Accelerated by a Solvent Effect.Synergistic Photoredox/Nickel Coupling of Acyl Chlorides with Secondary Alkyltrifluoroborates: Dialkyl Ketone Synthesis.Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness.Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical EntitiesCrown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells
P2860
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P2860
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Structure-activity relationshi ...... ug transporter P-glycoprotein.
@en
Structure-activity relationshi ...... ug transporter P-glycoprotein.
@nl
type
label
Structure-activity relationshi ...... ug transporter P-glycoprotein.
@en
Structure-activity relationshi ...... ug transporter P-glycoprotein.
@nl
altLabel
Structure–Activity Relationshi ...... rug Transporter P-Glycoprotein
@en
prefLabel
Structure-activity relationshi ...... ug transporter P-glycoprotein.
@en
Structure-activity relationshi ...... ug transporter P-glycoprotein.
@nl
P2093
P2860
P356
P1476
Structure-activity relationshi ...... ug transporter P-glycoprotein.
@en
P2093
Ishrat Jabeen
Karin Pleban
Peter Chiba
Uwe Rinner
P2860
P304
P356
10.1021/JM201705F
P407
P577
2012-03-27T00:00:00Z