Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. - Test2 - elhamkhani - TriplyDB

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

http://www.wikidata.org/entity/Q39595928

about

Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?Glucocerebrosidase is shaking up the synucleinopathies Extracellular Vesicles and a Novel Form of Communication in the Brain Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer's and Parkinson's Disease Neuroinflammation and Depression: Microglia Activation, Extracellular Microvesicles and microRNA Dysregulation Exosomes as Novel Regulators of Adult Neurogenic Niches Alpha-synuclein Toxicity in the Early Secretory Pathway: How It Drives Neurodegeneration in Parkinsons Disease miRNAs: biological and clinical determinants in epilepsy Disease-modifying therapeutic directions for Lewy-Body dementias Molecular diagnostics of neurodegenerative disorders The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods Glucocerebrosidase and Parkinson disease: Recent advances Protein degradation pathways in Parkinson's disease: curse or blessing Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics Depletion of microglia and inhibition of exosome synthesis halt tau propagation.Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease.Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes.Membrane remodeling and mechanics: Experiments and simulations of α-Synuclein Impact of lysosome status on extracellular vesicle content and release Insight of brain degenerative protein modifications in the pathology of neurodegeneration and dementia by proteomic profiling Alpha-synuclein spreading in Parkinson's disease Legal but lethal: functional protein aggregation at the verge of toxicity ATP13A2/PARK9 regulates secretion of exosomes and α-synuclein Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening Disease-toxicant interactions in Parkinson's disease neuropathology Application of the PAMONO-Sensor for Quantiﬁcation of Microvesicles and Determination of Nano-Particle Size Distribution Adsorption of α-synuclein to supported lipid bilayers: positioning and role of electrostatics Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients Considerations on the role of environmental toxins in idiopathic Parkinson's disease pathophysiology The role of extracellular vesicles in the progression of neurodegenerative disease and cancer Extracellular Vesicles as a Source of Urological Biomarkers: Lessons Learned From Advances and Challenges in Clinical Applications to Major Diseases.Exosomes in bodily fluids are a highly stable resource of disease biomarkers Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathies Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.The AAA-ATPase VPS4 regulates extracellular secretion and lysosomal targeting of α-synuclein.

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P2860

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

http://www.wikidata.org/entity/Q39595928

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Lysosomal dysfunction increase ...... lein release and transmission.

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Lysosomal dysfunction increase ...... lein release and transmission.

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type

label

Lysosomal dysfunction increase ...... lein release and transmission.

@en

Lysosomal dysfunction increase ...... lein release and transmission.

@nl

prefLabel

Lysosomal dysfunction increase ...... lein release and transmission.

@en

Lysosomal dysfunction increase ...... lein release and transmission.

@nl

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J.NBD.2011.01.029

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Neurobiology of Disease

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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

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Anthony H Schapira

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Ian L Sargent

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J Mark Cooper

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P2860

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

Alpha-synuclein in Lewy bodies

Chaperone-mediated autophagy markers in Parkinson disease brains

Staging of brain pathology related to sporadic Parkinson's disease

Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease

Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

Specificity and regulation of casein kinase-mediated phosphorylation of alpha-synuclein.

Identification of a structural motif crucial for infectivity of hepatitis B viruses

Exosome function: from tumor immunology to pathogen biology.

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10.1016/J.NBD.2011.01.029

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Matthew J. Wood

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49819792

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