Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation.
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Pathogenic mechanisms in centronuclear myopathiesThe BAR domain proteins: molding membranes in fission, fusion, and phagyClathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regenerationLet's go bananas: revisiting the endocytic BAR codeDefective membrane remodeling in neuromuscular diseases: insights from animal modelsDrosophila Nedd4-long reduces Amphiphysin levels in muscles and leads to impaired T-tubule formation.BIN1 localizes the L-type calcium channel to cardiac T-tubulesMutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathyAmphiphysin is a component of clathrin coats formed during synaptic vesicle recycling at the lamprey giant synapseMeta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's diseaseDisrupted membrane structure and intracellular Ca²⁺ signaling in adult skeletal muscle with acute knockdown of Bin1.Bin1 SRC homology 3 domain acts as a scaffold for myofiber sarcomere assemblyRole of amphiphysin II in somatostatin receptor trafficking in neuroendocrine cells.Bridging integrator 1 (Bin1) deficiency in zebrafish results in centronuclear myopathy.Regulation of Cardiomyocyte T-Tubular Structure: Opportunities for Therapy.Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.BAR the door: cancer suppression by amphiphysin-like genesCardiac tissue-specific repression of CELF activity disrupts alternative splicing and causes cardiomyopathy.Membrane traffic and muscle: lessons from human diseaseInhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains.Cardiac T-Tubule Microanatomy and Function.Dependence of cardiac transverse tubules on the BAR domain protein amphiphysin II (BIN-1)Altered splicing of the BIN1 muscle-specific exon in humans and dogs with highly progressive centronuclear myopathyT-tubule biogenesis and triad formation in skeletal muscle and implication in human diseases.Membrane traffic in skeletal muscle.BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes.Characterization of bridging integrator 1 (BIN1) as a potential tumor suppressor and prognostic marker in hepatocellular carcinomaThe BAR domain of amphiphysin is required for cleavage furrow tip-tubule formation during cellularization in Drosophila embryos.BIN1 regulates dynamic t-tubule membrane.Centronuclear (myotubular) myopathy.Transgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis.Moving and positioning the nucleus in skeletal muscle - one step at a timePredominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tractsJunctophilin-2 is necessary for T-tubule maturation during mouse heart development.AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling.Multilayered regulation of cardiac ion channels.Amphiphysin 2 (BIN1) in physiology and diseases.Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases.BAR domain proteins regulate Rho GTPase signaling.
P2860
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P2860
Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
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name
Targeted disruption of the mur ...... aberrant myofibril formation.
@en
Targeted disruption of the mur ...... aberrant myofibril formation.
@nl
type
label
Targeted disruption of the mur ...... aberrant myofibril formation.
@en
Targeted disruption of the mur ...... aberrant myofibril formation.
@nl
prefLabel
Targeted disruption of the mur ...... aberrant myofibril formation.
@en
Targeted disruption of the mur ...... aberrant myofibril formation.
@nl
P2093
P2860
P1476
Targeted disruption of the mur ...... h aberrant myofibril formation
@en
P2093
Alejandro Peralta Soler
Arthur H Roach
Christian Reid
George C Prendergast
George Farmer
James B DuHadaway
Judith F Baker
Neelima Shah
P Scott Donover
Raymond Meade
P2860
P304
P356
10.1128/MCB.23.12.4295-4306.2003
P407
P577
2003-06-01T00:00:00Z