Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
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Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activationStructural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1Activated RhoA Binds to the Pleckstrin Homology (PH) Domain of PDZ-RhoGEF, a Potential Site for AutoregulationStructural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complexTuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeletonStructural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factorCcpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor DbsDedicator of Cytokinesis 2 in Cell Signaling Regulation and Disease Development.Regulation of vesicle transport and cell motility by Golgi-localized Dbs.Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state.Intersectin-1L nucleotide exchange factor regulates secretory granule exocytosis by activating Cdc42Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula.Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay.Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assayStructure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1.The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes.Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminalsMembrane recognition and targeting by lipid-binding domains.Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis.ROCK I-mediated activation of NF-kappaB by RhoBStructural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.Allosteric properties of PH domains in Arf regulatory proteins.Dynamic interaction between Arf GAP and PH domains of ASAP1 in the regulation of GAP activityFrabin and other related Cdc42-specific guanine nucleotide exchange factors couple the actin cytoskeleton with the plasma membraneThe rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.A PH domain in the Arf GTPase-activating protein (GAP) ARAP1 binds phosphatidylinositol 3,4,5-trisphosphate and regulates Arf GAP activity independently of recruitment to the plasma membranes.Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.Crossroads of PI3K and Rac pathways.Leukocyte transendothelial migration: A local affair.Conserved domains subserve novel mechanisms and functions in DKF-1, a Caenorhabditis elegans protein kinase D.The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity.Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF.Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).Transformation by the Rho-specific guanine nucleotide exchange factor Dbs requires ROCK I-mediated phosphorylation of myosin light chain.A phosphatidylserine-binding site in the cytosolic fragment of Clostridium sordellii lethal toxin facilitates glucosylation of membrane-bound Rac and is required for cytotoxicity.
P2860
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P2860
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
description
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im Mai 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/05/16)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/05/16)
@nl
наукова стаття, опублікована в травні 2003
@uk
name
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
@ast
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
@en
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
@nl
type
label
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
@ast
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
@en
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
@nl
prefLabel
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
@ast
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
@en
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
@nl
P2093
P2860
P356
P1476
Multifunctional roles for the PH domain of Dbs in regulating Rho GTPase activation
@en
P2093
Gwendolyn M. Mahon
Ian P. Whitehead
Jason T. Snyder
Kent L. Rossman
Rafael J. Rojas
P2860
P304
18393–18400
P356
10.1074/JBC.M300127200
P407
P50
P577
2003-05-16T00:00:00Z