Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting
about
Type I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activationThe DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activationThe Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidanceStructural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1Activated RhoA Binds to the Pleckstrin Homology (PH) Domain of PDZ-RhoGEF, a Potential Site for AutoregulationThe Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor IntersectinStructural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factorEpithelial junctions and Rho family GTPases: the zonular signalosome.The pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac.Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1.Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase.Phosphatidylinositol 3-kinase plays a vital role in regulation of rice seed vigor via altering NADPH oxidase activity.TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway.The R-Ras/RIN2/Rab5 complex controls endothelial cell adhesion and morphogenesis via active integrin endocytosis and Rac signalingSLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.Emerging roles of phosphatidylinositol 3-monophosphate as a dynamic lipid second messenger.Pleckstrin homology (PH) domains and phosphoinositides.Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.The role of small GTPases in neuronal morphogenesis and polarity.Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.Crossroads of PI3K and Rac pathways.Involvement of Tiam1, RhoG and ELMO2/ILK in Rac1-mediated phagocytosis in human trabecular meshwork cells.PI5P and PI(3,5)P2: Minor, but Essential Phosphoinositides.Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1PAR3-aPKC regulates Tiam1 by modulating suppressive internal interactionsThe Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity.C-terminal di-arginine motif of Cdc42 protein is essential for binding to phosphatidylinositol 4,5-bisphosphate-containing membranes and inducing cellular transformationCritical role of the pleckstrin homology domain in Dbs signaling and growth regulation.The Tiam1 guanine nucleotide exchange factor is auto-inhibited by its pleckstrin homology coiled-coil extension domain.Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1.Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae.
P2860
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P2860
Loss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targeting
description
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2003
@ast
im März 2003 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2003/03/28)
@sk
vědecký článek publikovaný v roce 2003
@cs
wetenschappelijk artikel (gepubliceerd op 2003/03/28)
@nl
наукова стаття, опублікована в березні 2003
@uk
name
Loss of phosphatidylinositol 3 ...... t affecting membrane targeting
@ast
Loss of phosphatidylinositol 3 ...... t affecting membrane targeting
@en
Loss of phosphatidylinositol 3 ...... t affecting membrane targeting
@nl
type
label
Loss of phosphatidylinositol 3 ...... t affecting membrane targeting
@ast
Loss of phosphatidylinositol 3 ...... t affecting membrane targeting
@en
Loss of phosphatidylinositol 3 ...... t affecting membrane targeting
@nl
prefLabel
Loss of phosphatidylinositol 3 ...... t affecting membrane targeting
@ast
Loss of phosphatidylinositol 3 ...... t affecting membrane targeting
@en
Loss of phosphatidylinositol 3 ...... t affecting membrane targeting
@nl
P2093
P2860
P921
P356
P1476
Loss of phosphatidylinositol 3 ...... t affecting membrane targeting
@en
P2093
Kent L. Rossman
Lenka Martinu
Margaret M. Chou
Mark A. Baumeister
P2860
P304
11457–11464
P356
10.1074/JBC.M211901200
P407
P577
2003-03-28T00:00:00Z