Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling. - Test2 - elhamkhani - TriplyDB

Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.

Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.

http://www.wikidata.org/entity/Q39954565

about

Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway Regulation of TOR by small GTPases Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting Regulation of mTORC1 by PI3K signaling Molecular Basis of the Acceleration of the GDP-GTP Exchange of Human Ras Homolog Enriched in Brain by Human Translationally Controlled Tumor Protein A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding Structure-guided Mutation of the Conserved G3-box Glycine in Rheb Generates a Constitutively Activated Regulator of Mammalian Target of Rapamycin (mTOR)Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling.Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL Characterization of the pumpkin Translationally-Controlled Tumor Protein CmTCTP.Structural divergence of plant TCTPs Hepatitis C virus NS5A activates the mammalian target of rapamycin (mTOR) pathway, contributing to cell survival by disrupting the interaction between FK506-binding protein 38 (FKBP38) and mTOR Neighborhood properties are important determinants of temperature sensitive mutations.TOR signaling never gets old: aging, longevity and TORC1 activity.The abundance and activation of mTORC1 regulators in skeletal muscle of neonatal pigs are modulated by insulin, amino acids, and age.The Long-HER study: clinical and molecular analysis of patients with HER2+ advanced breast cancer who become long-term survivors with trastuzumab-based therapy.Direct Interaction between Ras Homolog Enriched in Brain and FK506 Binding Protein 38 in Cashmere Goat Fetal Fibroblast Cells.Rab-family GTPase regulates TOR complex 2 signaling in fission yeast Functional amino acids in growth, reproduction, and health.Translationally controlled tumor protein induces epithelial to mesenchymal transition and promotes cell migration, invasion and metastasis Regulation of protein synthesis by amino acids in muscle of neonates.Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect.FKBP38 peptidylprolyl isomerase promotes the folding of cystic fibrosis transmembrane conductance regulator in the endoplasmic reticulum RalA functions as an indispensable signal mediator for the nutrient-sensing system mTor signaling in skeletal muscle during sepsis and inflammation: where does it all go wrong?The sensing of essential amino acid deficiency in the anterior piriform cortex, that requires the uncharged tRNA/GCN2 pathway, is sensitive to wortmannin but not rapamycin.PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects.Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment.Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin.Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth.Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells.Distinctive responses to nitrogen starvation in the dominant active mutants of the fission yeast Rheb GTPase.The Plasmodium falciparum translationally controlled tumor protein (TCTP) is incorporated more efficiently into B cells than its human homologue.Autophagy: regulation and role in disease.Key factors in mTOR regulation.Translationally controlled tumour protein TCTP is induced early in human colorectal tumours and contributes to the resistance of HCT116 colon cancer cells to 5-FU and oxaliplatin.Molecular mechanisms of metabolic regulation by insulin in Drosophila.

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P2860

Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.

http://www.wikidata.org/entity/Q39954565

description

2008 nî lūn-bûn

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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name

Re-evaluating the roles of pro ...... complex 1 (mTORC1) signaling.

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Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1

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type

label

Re-evaluating the roles of pro ...... complex 1 (mTORC1) signaling.

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Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1

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prefLabel

Re-evaluating the roles of pro ...... complex 1 (mTORC1) signaling.

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Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1

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Re-evaluating the roles of pro ...... complex 1 (mTORC1) signaling.

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Androulla Elia

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Bruno D Fonseca

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Hua Tang

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Michael J Clemens

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Rui Liu

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Xuemin Wang

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P2860

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins.

Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin.

A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A

A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

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30482-30492

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10.1074/JBC.M803348200

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45

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283

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Christopher G. Proud

Ulrich-Axel Bommer

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2008-08-01T00:00:00Z

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23145690

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18676370

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2662142

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