Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.
about
Uracil-containing DNA in Drosophila: stability, stage-specific accumulation, and developmental involvementCheckpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stressUracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed.A one-step method for quantitative determination of uracil in DNA by real-time PCR.Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.Genomically Incorporated 5-Fluorouracil that Escapes UNG-Initiated Base Excision Repair Blocks DNA Replication and Activates Homologous RecombinationDetection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications.5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase.Participation of DNA repair in the response to 5-fluorouracil.Uracil in DNA: consequences for carcinogenesis and chemotherapyVpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA.Uracil DNA glycosylase (UNG) loss enhances DNA double strand break formation in human cancer cells exposed to pemetrexedInhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage.Glycogen Synthase Kinase 3 (GSK-3)-mediated Phosphorylation of Uracil N-Glycosylase 2 (UNG2) Facilitates the Repair of Floxuridine-induced DNA Lesions and Promotes Cell Survival.1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells.Cytotoxicity and genotoxicity of capecitabine in head and neck cancer and normal cells.DNA damage and homologous recombination signaling induced by thymidylate deprivation.Expression and regulation of RAD51 mediate cellular responses to chemotherapeutics.dUTPase inhibition augments replication defects of 5-Fluorouracil.The Stl repressor from Staphylococcus aureus is an efficient inhibitor of the eukaryotic fruitfly dUTPase.Structural model of human dUTPase in complex with a novel proteinaceous inhibitor.
P2860
Q27333589-0BBE1A39-A74B-437F-8206-B13D8AA0C558Q34110442-0A0F5752-E349-4A87-9ACC-A6690ACDFEEAQ34318584-DE324A12-F4EF-4B36-8501-2FA82B83728AQ34364597-4B376141-553B-4FF4-8B30-F1C3F108AED4Q34368159-EC53ED40-A8FA-4FEA-B960-0050EDBBAF0DQ34782000-E613D524-AE99-4DCF-8229-C90B4A738300Q35447633-3CC57E98-4B94-4B60-8648-BACB8EC8735CQ36432422-89362791-EB61-4EED-9085-E74F7071A749Q36588979-670D8E73-0175-4045-B1D9-AC1EA95790DBQ36793966-F733BB6E-1EEA-4E0D-94E6-E23933D52102Q36981985-D7A52DFA-864C-4913-9F10-5E460F1086B7Q37114275-A758AC9F-B5D5-43AE-9908-D8AF531C56AAQ37206564-9BA2E30B-7345-4539-96A7-89869627988EQ37574121-08EFF743-4613-408B-8F7E-255EC68AC6FCQ37620609-A3DBC279-0865-4E4C-8DD9-B80277315137Q37644861-CE85BAEC-4583-416E-8705-6BE2638487F4Q38729647-40461FC5-D761-4F80-B5FA-EDD4436E998BQ39060025-BD49FCF3-7D0F-4A50-8A69-02E939F7569CQ39627590-C25AAEDC-CF66-45E7-987E-E1C89EB97C17Q39942882-00FF75EB-D33D-4B15-9044-3A65F0F7132AQ41077343-202996DD-FAA2-4522-B5AC-6F979F2092BDQ41767730-17C21BA2-61FA-4B55-B544-CE02543CF334Q50052283-075F003C-C30F-4128-8353-2A1397C849F6Q51741046-BEDD3280-01E4-4AC4-BDA2-6A440AA84A93
P2860
Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Uracil incorporation into geno ...... ition of thymidylate synthase.
@en
type
label
Uracil incorporation into geno ...... ition of thymidylate synthase.
@en
prefLabel
Uracil incorporation into geno ...... ition of thymidylate synthase.
@en
P2860
P1433
P1476
Uracil incorporation into geno ...... bition of thymidylate synthase
@en
P2093
Mike Walla
Yuhong Luo
P2860
P304
P356
10.1016/J.DNAREP.2007.09.001
P577
2007-10-17T00:00:00Z