Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport.
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Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channelsAirway surface liquid volume regulation determines different airway phenotypes in liddle compared with betaENaC-overexpressing miceSPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavageNeutrophil elastase and matrix metalloproteinase 12 in cystic fibrosis lung diseaseENaC regulation by proteases and shear stressNeutrophil plasticity enables the development of pathological microenvironments: implications for cystic fibrosis airway diseaseAirway hydration and COPDRegulation and dysregulation of epithelial Na+ channelsActivation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosaInhibition of human neutrophil elastase by pentacyclic triterpenesBenzamil sensitive ion channels contribute to volume regulation in canine chondrocytesPlasmin activates epithelial Na+ channels by cleaving the gamma subunit.A segment of gamma ENaC mediates elastase activation of Na+ transportPlasmin in nephrotic urine activates the epithelial sodium channel8-pCPT-cGMP stimulates alphabetagamma-ENaC activity in oocytes as an external ligand requiring specific nucleotide moietiesNeutrophil responses to injury or inflammation impair peripheral gustatory functionNew role for plasmin in sodium homeostasis.Regulation of sodium transport by ENaC in the kidneyRegulation of the epithelial sodium channel (ENaC) by membrane traffickingDefining an inhibitory domain in the gamma subunit of the epithelial sodium channelProteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension.ERp29 regulates epithelial sodium channel functional expression by promoting channel cleavage.Lack of neutrophil elastase reduces inflammation, mucus hypersecretion, and emphysema, but not mucus obstruction, in mice with cystic fibrosis-like lung disease.The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulationLiddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage.Acute cholesterol-induced anti-natriuretic effects: role of epithelial Na+ channel activity, protein levels, and processing.Activation of the epithelial sodium channel by the metalloprotease meprin β subunit.The epithelial sodium channel γ-subunit is processed proteolytically in human kidney.Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibitionCpt-cAMP activates human epithelial sodium channels via relieving self-inhibitionProteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites.Increased folding and channel activity of a rare cystic fibrosis mutant with CFTR modulators.ENaC structure and function in the wake of a resolved structure of a family member.Sodium retention and volume expansion in nephrotic syndrome: implications for hypertension.Hypoxic epithelial necrosis triggers neutrophilic inflammation via IL-1 receptor signaling in cystic fibrosis lung disease.Inositol polyphosphate derivative inhibits Na+ transport and improves fluid dynamics in cystic fibrosis airway epithelia.TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage siteENaCs and ASICs as therapeutic targets.Hsp70 promotes epithelial sodium channel functional expression by increasing its association with coat complex II and its exit from endoplasmic reticulum.
P2860
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P2860
Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Neutrophil elastase activates ...... rway epithelial Na+ transport.
@en
type
label
Neutrophil elastase activates ...... rway epithelial Na+ transport.
@en
prefLabel
Neutrophil elastase activates ...... rway epithelial Na+ transport.
@en
P2093
P2860
P1476
Neutrophil elastase activates ...... rway epithelial Na+ transport.
@en
P2093
M Jackson Stutts
Ray A Caldwell
Richard C Boucher
P2860
P304
P356
10.1152/AJPLUNG.00435.2004
P577
2005-01-07T00:00:00Z