The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein.
about
Allosteric activation of the protein kinase PDK1 with low molecular weight compoundsCrystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP-PNPCrystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitorsStructural Diversity of the Active N-Terminal Kinase Domain of p90 Ribosomal S6 Kinase 2The Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor.Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylationThe unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides.Mitogen- and stress-activated kinases regulate progenitor cell proliferation and neuron development in the adult dentate gyrus.MSK2 inhibits p53 activity in the absence of stress.Reconstitution of modular PDK1 functions on trans-splicing of the regulatory PH and catalytic kinase domainsA Rising Cancer Prevention Target of RSK2 in Human Skin Cancer.A derivative of chrysin suppresses two-stage skin carcinogenesis by inhibiting mitogen- and stress-activated kinase 1.Targeting the unactivated conformations of protein kinases for small molecule drug discovery.cAMP-response element-binding protein (CREB) controls MSK1-mediated phosphorylation of histone H3 at the c-fos promoter in vitro.Activity and cellular localization of an oncogenic glioblastoma multiforme-associated EGF receptor mutant possessing a duplicated kinase domain.Regulation of the interaction between protein kinase C-related protein kinase 2 (PRK2) and its upstream kinase, 3-phosphoinositide-dependent protein kinase 1 (PDK1).Identification of novel phosphorylation sites in MSK1 by precursor ion scanning MS.Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.MSK1 activity is controlled by multiple phosphorylation sites.Molecular Modeling of Differentially Phosphorylated Serine 10 and Acetylated lysine 9/14 of Histone H3 Regulates their Interactions with 14-3-3ζ, MSK1, and MKP1.Inhibition of p90 ribosomal S6 kinase-mediated CCAAT/enhancer-binding protein beta activation and cyclooxygenase-2 expression by salicylate.Allosteric regulation of PKCθ: understanding multistep phosphorylation and priming by ligands in AGC kinases.PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity.The multifaceted allosteric regulation of Aurora kinase A.
P2860
Q24317058-0F1937C4-0DA6-43F9-A861-E99D1133DC74Q27648914-818E8808-1EED-4409-9851-1E09FE400D1BQ27648916-C2CA4A06-5CD5-43A1-9D02-6A715C5F9C47Q27658416-131A8624-09CE-4280-A319-698F9FB932CEQ27660474-19FCA278-B5B3-4973-BE82-93519E099802Q27670966-9FB2099D-8BFB-494B-BF62-8C60DC4451FDQ28568275-2418CB0F-A8A1-4E65-9304-9D35CAA5712FQ30412077-7277B1F9-5A8D-47D6-9229-FA9DDBC65FE6Q36619639-FEC843E6-FABE-481F-9AE6-BD224E0AF001Q36832839-B076FBFB-76B5-48A9-905A-7DB401997407Q36851665-2FEB1031-1D5C-4FAB-9DF6-B7C6AE862429Q37068772-926DBD1A-AFE5-4A94-AC7C-9C94C19DD7A8Q37626140-357EFCB1-02C4-402B-8537-C98960C9030FQ38090668-34594A06-8781-45DE-A7AC-CE24F49898AEQ39737970-B9543259-BA82-4F29-BA02-DB586B9D5235Q39774256-36442B6A-402E-4D8A-A055-705ECCE1502EQ39805182-A8572276-5B7E-4B64-BD02-2625687DB0E8Q40206010-7A2A4DA7-CB80-48D9-B977-C82C1334EEB4Q40452176-1BDFC7E9-FBF6-42AE-B24C-6F2680B41612Q40487132-C882C161-752E-40A9-9114-53963FD2360EQ41858644-6CBC1C97-D638-42C9-B5D6-DA3496ED76C9Q45287586-68FD5774-1BE0-44EA-9F7C-5589EB0C1879Q45346177-42485D74-4A70-41E8-8E4B-A7CF6903CD0DQ45998535-C59BC487-2E42-49CD-9548-D33F4F4BA9A6Q55486788-A3B97B3F-C958-43A6-AFC3-6B3A080B1315
P2860
The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The structure of MSK1 reveals ...... ion for a dual kinase protein.
@en
type
label
The structure of MSK1 reveals ...... ion for a dual kinase protein.
@en
prefLabel
The structure of MSK1 reveals ...... ion for a dual kinase protein.
@en
P2093
P1433
P1476
The structure of MSK1 reveals ...... tion for a dual kinase protein
@en
P2093
Alastair Reith
Andrew Clarke
Angela Bridges
Ceri Lewis
Gary Pettman
Jane Hughes
Kathrine J Smith
Marc Wilkinson
Murray Brown
Paul S Carter
P304
P356
10.1016/J.STR.2004.02.040
P50
P577
2004-06-01T00:00:00Z