Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
about
Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Current views on the potential for development of a HIV vaccine.Stabilized HIV-1 envelope glycoprotein trimers for vaccine use.Glycosylation of the core of the HIV-1 envelope subunit protein gp120 is not required for native trimer formation or viral infectivity.Progress toward active or passive HIV-1 vaccination.Vaccine nanoparticles for protection against HIV infection.Evaluation of a novel multi-immunogen vaccine strategy for targeting 4E10/10E8 neutralizing epitopes on HIV-1 gp41 membrane proximal external region.Immunization with HIV-1 envelope T20-encoding DNA vaccines elicits cross-clade neutralizing antibody responses.Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies.Increased frequencies of CD8+CD57+ T cells are associated with antibody neutralization breadth against HIV in viraemic controllers.Towards functional antibody-based vaccines to prevent pre-erythrocytic malaria infection.How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.Development of an HIV vaccine using a vesicular stomatitis virus vector expressing designer HIV-1 envelope glycoproteins to enhance humoral responses.Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability.What Are the Most Powerful Immunogen Design Vaccine Strategies? Reverse Vaccinology 2.0 Shows Great Promise.Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25.Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens.Epitope-focused immunogens against the CD4-binding site of HIV-1 envelope protein induce neutralizing antibodies against auto- and heterologous viruses.The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogenStrategies for a multi-stage neutralizing antibody-based HIV vaccineProtein design: from computer models to artificial intelligenceElectron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer ImmunizationDevelopment of broadly neutralizing antibodies in HIV-1 infected elite neutralizersWhen designing vaccines, consider the starting material: the human B cell repertoireAdvanced model systems and tools for basic and translational human immunology
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P2860
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
@en
type
label
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
@en
prefLabel
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
@en
P2093
P2860
P356
P1433
P1476
Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice
@en
P2093
Alejandra Ramos
Andrew Wood
Bryan Briney
Daniel W Kulp
Dennis R Burton
E-Chiang Lee
Glenn A Friedrich
Joseph G Jardine
P2860
P304
P356
10.1126/SCIENCE.AAH3945
P407
P577
2016-09-08T00:00:00Z