Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
about
DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.DNA polymerase γ and disease: what we have learned from yeastThe Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore †Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide ReductaseThe protein kinase Snf1 is required for tolerance to the ribonucleotide reductase inhibitor hydroxyureaInhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme.Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.Yeast DNA damage-inducible Rnr3 has a very low catalytic activity strongly stimulated after the formation of a cross-talking Rnr1/Rnr3 complex.Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulationNuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.Hug1 is an intrinsically disordered protein that inhibits ribonucleotide reductase activity by directly binding Rnr2 subunit.Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathwaysLCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiaeIdentification and characterization of CRT10 as a novel regulator of Saccharomyces cerevisiae ribonucleotide reductase genes.Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit.The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage.Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression.The Schizosaccharomyces pombe replication inhibitor Spd1 regulates ribonucleotide reductase activity and dNTPs by binding to the large Cdc22 subunitIdentification of phosphorylation sites on the yeast ribonucleotide reductase inhibitor Sml1.Excess single-stranded DNA inhibits meiotic double-strand break repair.Dif1 controls subcellular localization of ribonucleotide reductase by mediating nuclear import of the R2 subunitNormally lethal amino acid substitutions suppress an ultramutator DNA Polymerase δ variantMutational and structural analyses of the ribonucleotide reductase inhibitor Sml1 define its Rnr1 interaction domain whose inactivation allows suppression of mec1 and rad53 lethalityNatural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.Yeast Dun1 kinase regulates ribonucleotide reductase inhibitor Sml1 in response to iron deficiencyTransactivation of Schizosaccharomyces pombe cdt2+ stimulates a Pcu4-Ddb1-CSN ubiquitin ligaseLoss of SOD1 and LYS7 sensitizes Saccharomyces cerevisiae to hydroxyurea and DNA damage agents and downregulates MEC1 pathway effectorsThe ribonucleotide reductase inhibitor, Sml1, is sequentially phosphorylated, ubiquitylated and degraded in response to DNA damageStructures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly.Cotransport of the heterodimeric small subunit of the Saccharomyces cerevisiae ribonucleotide reductase between the nucleus and the cytoplasmLoss of APD1 in yeast confers hydroxyurea sensitivity suppressed by Yap1p transcription factordNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Regulation of ribonucleotide reductase in response to iron deficiency.Dif1 is a DNA-damage-regulated facilitator of nuclear import for ribonucleotide reductase.Role of the C terminus of the ribonucleotide reductase large subunit in enzyme regeneration and its inhibition by Sml1A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development.Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy.Telomere length homeostasis responds to changes in intracellular dNTP pools.Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae.
P2860
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P2860
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
description
1999 nî lūn-bûn
@nan
1999 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
@ast
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
@en
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
@nl
type
label
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
@ast
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
@en
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
@nl
prefLabel
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
@ast
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
@en
Yeast Sml1, a protein inhibitor of ribonucleotide reductase.
@nl
P2860
P3181
P356
P1476
Yeast Sml1, a protein inhibitor of ribonucleotide reductase
@en
P2093
P2860
P304
36679-36683
P3181
P356
10.1074/JBC.274.51.36679
P407
P577
1999-12-01T00:00:00Z