Multiple functions for the invariant AGC triad of U6 snRNA.
about
Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centreThe N- and C-terminal RNA recognition motifs of splicing factor Prp24 have distinct functions in U6 RNA bindingNew insights into the spliceosome by single molecule fluorescence microscopyStructure and thermodynamics of a conserved U2 snRNA domain from yeast and humanStructure of the yeast U2/U6 snRNA complexCrystal structure of Cwc2 reveals a novel architecture of a multipartite RNA-binding proteinThe DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome.Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicingCEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.Structure of a self-splicing group II intron catalytic effector domain 5: parallels with spliceosomal U6 RNARNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.RNA catalyses nuclear pre-mRNA splicingEvidence for a group II intron-like catalytic triplex in the spliceosomeSingle-molecule analysis of protein-free U2-U6 snRNAs.Cross-linking, ligation, and sequencing of hybrids reveals RNA-RNA interactions in yeast.Spliceosome assembly in the absence of stable U4/U6 RNA pairing.U2 toggles iteratively between the stem IIa and stem IIc conformations to promote pre-mRNA splicingThree essential and conserved regions of the group II intron are proximal to the 5'-splice site.Free energy landscapes of RNA/RNA complexes: with applications to snRNA complexes in spliceosomes.Spliceosomal snRNAs in the unicellular eukaryote Trichomonas vaginalis are structurally conserved but lack a 5'-cap structure.The spliceosome: a ribozyme at heart?Conformational heterogeneity of the protein-free human spliceosomal U2-U6 snRNA complexThe EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPase"Nought may endure but mutability": spliceosome dynamics and the regulation of splicing.A glimpse into the active site of a group II intron and maybe the spliceosome, too.Splicing of mRNA precursors: the role of RNAs and proteins in catalysis.Structural insights into RNA splicing.The mechanism of the second step of pre-mRNA splicing.Lights, camera, action! Capturing the spliceosome and pre-mRNA splicing with single-molecule fluorescence microscopy.Evolution of small nuclear RNAs in S. cerevisiae, C. albicans, and other hemiascomycetous yeasts.Emerging views about the molecular structure of the spliceosomal catalytic center.A protein map of the yeast activated spliceosome as obtained by electron microscopyEvidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps.Metal binding and substrate positioning by evolutionarily invariant U6 sequences in catalytically active protein-free snRNAs.Mutation in the U2 snRNA influences exon interactions of U5 snRNA loop 1 during pre-mRNA splicing.Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome.Remodeling of U2-U6 snRNA helix I during pre-mRNA splicing by Prp16 and the NineTeen Complex protein Cwc2Proximity of the U12 snRNA with both the 5' splice site and the branch point during early stages of spliceosome assemblyPost-transcriptional modifications modulate conformational dynamics in human U2-U6 snRNA complex.Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomes.
P2860
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P2860
Multiple functions for the invariant AGC triad of U6 snRNA.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Multiple functions for the invariant AGC triad of U6 snRNA.
@en
type
label
Multiple functions for the invariant AGC triad of U6 snRNA.
@en
prefLabel
Multiple functions for the invariant AGC triad of U6 snRNA.
@en
P2860
P356
P1433
P1476
Multiple functions for the invariant AGC triad of U6 snRNA.
@en
P2093
Angela K Hilliker
Jonathan P Staley
P2860
P304
P356
10.1261/RNA.7310704
P407
P577
2004-06-01T00:00:00Z